Anomalous Fetal and Neonatal Bone Development Induced by Administration of Cortisone and Vitamin D2 to Pregnant Rats
Several teratogenic agents may cause skeletal anomalies. Since the pioneering studies of Warkany and Nelson, who described a pattern of skeletal anomalies in rat fetuses following nutritional deficiency in the pregnant mother (1,2), teratogens such as alkylating agents have been found also to cause skeletal anomalies in the offspring (3,4). However, in most cases the anomalies were not in the whole skeleton, and normal as well as abnormal bones could be found concomitantly. In our experiments we endeavored to explore whether, by administration of substances such as vitamin D and cortisone to pregnant mothers, the fetal skeleton could be affected as a whole. These substances are already known to have an effect on the skeletal system (5,6).
KeywordsOsteogenesis Imperfecta Pregnant Mother Skeletal Anomaly Cortisone Acetate Bone Marrow Cavity
Unable to display preview. Download preview PDF.
- 1.WARKANY, J. NELSON, R.C. Arch. Path. 34: 375, 1942.Google Scholar
- 2.WARKANY, J. Am. J. Dis. Child. 66: 511, 1943.Google Scholar
- 5.ORNOY, A., NEBEL, L. MENCZEL, J. Arch. Path. 87: 563, 1969.Google Scholar
- 11.WEBER, M. Arch. Path. 9: 984, 1930.Google Scholar
- 12.SCARPELI, D.G., TREMBLAY, G. PEARCE, A.G. E. Amer. J. Path. 36: 331, 1960.Google Scholar