Limb Malformation Production in Chicken Embryos Treated with Nitrogen Mustard at 48 Hours of Incubation

  • B. Salzgeber
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 27)


Nitrogen mustard (methyl bis chloroethylamine hydrochloride), a radiomimetic and cytotoxic agent, has proved to be also a powerful teratogenic agent. When administered to vertebrate embryos at a particular stage of development and at doses which allow survival of the embryo, nitrogen mustard produces a very similar type of malformation in different animal species. Limb malformations were obtained in amphibians, mammals and birds (1,2).


Chick Embryo Nitrogen Mustard Embryological Study Apical Ectodermal Ridge Limb Malformation 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • B. Salzgeber
    • 1
  1. 1.Institut d’Embryologie et de Tératologie Expérimentalesdu C.N.R.S. et du College de FranceNogent s/MarneFrance

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