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Limb Malformation Production in Chicken Embryos Treated with Nitrogen Mustard at 48 Hours of Incubation

  • B. Salzgeber
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 27)

Abstract

Nitrogen mustard (methyl bis chloroethylamine hydrochloride), a radiomimetic and cytotoxic agent, has proved to be also a powerful teratogenic agent. When administered to vertebrate embryos at a particular stage of development and at doses which allow survival of the embryo, nitrogen mustard produces a very similar type of malformation in different animal species. Limb malformations were obtained in amphibians, mammals and birds (1,2).

Keywords

Chick Embryo Nitrogen Mustard Embryological Study Apical Ectodermal Ridge Limb Malformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • B. Salzgeber
    • 1
  1. 1.Institut d’Embryologie et de Tératologie Expérimentalesdu C.N.R.S. et du College de FranceNogent s/MarneFrance

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