Phenothiazine Tranquillizers: Effect of Prolonged Intake
Widespread use of phenothiazine tranquillizers has led to concern with regard to their side-effects, particularly in cases of liver dysfunctions and in pregnancy (1). Liver cirrhosis and jaundice, for example, are known to enhance significantly the action of phenothiazines (2). Effects of phenothiazine on endocrine functions have been reported (3). At the Neurotoxicology Research Unit, tissues obtained at autopsies of patients with liver pathology who were treated with chlorpromazine were often characterized by an abnormally high phenothiazine content, as were also the tissues of experimental animals with liver lesions induced by chronic ethionine treatment (4,5).
KeywordsPregnancy Rate Floor Plate Federation Proc Mental Hygiene York State Department
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