Phenothiazine Tranquillizers: Effect of Prolonged Intake

  • George J. Alexander
  • Sandra Machiz
  • Rita B. Alexander
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 27)


Widespread use of phenothiazine tranquillizers has led to concern with regard to their side-effects, particularly in cases of liver dysfunctions and in pregnancy (1). Liver cirrhosis and jaundice, for example, are known to enhance significantly the action of phenothiazines (2). Effects of phenothiazine on endocrine functions have been reported (3). At the Neurotoxicology Research Unit, tissues obtained at autopsies of patients with liver pathology who were treated with chlorpromazine were often characterized by an abnormally high phenothiazine content, as were also the tissues of experimental animals with liver lesions induced by chronic ethionine treatment (4,5).


Pregnancy Rate Floor Plate Federation Proc Mental Hygiene York State Department 


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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • George J. Alexander
    • 1
  • Sandra Machiz
    • 1
  • Rita B. Alexander
    • 1
  1. 1.Neurotoxicology Research UnitNew York State Department of Mental HygieneNew YorkUSA

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