Chemistry and Metabolism of Glycopeptides Derived from Brain Glycoproteins

  • E. G. Brunngraber
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 25)


Research advances in the field of neural glycoproteins have been reviewed (1, 2, 3). The present article will focus attention on the chemistry and metabolism of the heteropolysaccharide chains that are associated with the brain glycoproteins. Another article in this volume will focus attention on changes induced in these substances as a consequence of neural pathology. A glycoprotein is a protein that has attached to it one or more carbohydrate groups. Such carbohydrate groups may be quite simple, consisting of a single carbohydrate residue or simple di-, tri- or oligosaccharides. At the other extreme, glycoproteins may contain one or more complex, highly branched, heteropolysaccharide chains. As a rule, the predominant sugars in such heteropolysaccharide chains are N-acetylneuraminic acid (NANA), mannose, galactose, N-acetylglucosamine, and fucose. N-acetylgalactosamine is often present in such chains. Glucose has been reported to be present in several glycoproteins, but this sugar is only rarely present in glycoprotein material.


Mannose Residue Synaptosomal Membrane Mild Acid Hydrolysis Standardize Column High Electrophoretic Mobility 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • E. G. Brunngraber
    • 1
  1. 1.Illinois State Psychiatric InstituteChicagoUSA

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