Effect of Exercise on Development of Atherosclerosis in Swine

  • Roger P. Link
  • Waldir M. Pedersoli
  • Alvin H. Safanie
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 241)


Few clinical problems in medicine are more beclouded than the relationship between physicial activity and atherosclerosis (1). It has been difficult to evaluate the relationship between exercise and atherosclerosis because of lack of uniformity of conditions under which data have been obtained. Morris et al (2), in a study of 31,000 men ages 35 to 64, found those in occupations requiring physical activity had a lower incidence of heart disease in middle age than those in sedentary occupations. It has been demonstrated in a small sampling of human subjects that doubling the caloric intake of young men did not increase the serum lipoproteins and cholesterol concentrations as long as the surplus energy was expended as heat and muscular energy. Accretion of the excess energy as adipose tissue was accompanied by increase in serum lipids in 67 per cent of the subjects (3). A study of the occurrence of sudden death from coronary atherosclerosis and its relationship with age, sex, race, alcohol consumption and physical activity revealed that strenuous activity was infrequently associated with acute coronary occlusion immediately preceding death (4).


Total Lipid Serum Cholesterol Basilar Artery Coronary Atherosclerosis Fatty Streak 
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  1. 1.
    Moses, G. Atherosclerosis. Mechanisms as a guide to protection. Lea and Febiger, Philadelphia, Pennsylvania, 1963.Google Scholar
  2. 2.
    Morris, J.N., Heady, J.A., Raffle, P.A.B., Roberts, C.G., and Parks, J.W. Coronary heart disease and physical activity of work. Lancet 2: 1053–11, 1953.CrossRefGoogle Scholar
  3. 3.
    Mann, G.V., Teal, K., Hayes, O., McNally, A. and Bruno, W. Exercise in the disposition of dietary calories. New Eng. J. Med. 253: 349–354, 1955.PubMedCrossRefGoogle Scholar
  4. 4.
    Spain, D.M. and Bradess, V.A.: Sudden death from coronary atherosclerosis. Age, race, sex, physicial activity and alcohol. Arch. Intern. Med. 100: 228–231, 1957.CrossRefGoogle Scholar
  5. 5.
    Morris, J.N. and Crawford, M.D.: Coronary heart disease and physical activity of work. Evidence of national necropsy survey. Brit. Med. J. 2: 1485–1496, 1958.PubMedCrossRefGoogle Scholar
  6. 6.
    Pomeroy, W.C. and White, P.D. Coronary heart disease in former football players. J.A.M.A. 167: 711–714, 1958.CrossRefGoogle Scholar
  7. 7.
    Raab, W. Loafer’s heart. Arch. Intern. Med. 10: 194–198, 1958.Google Scholar
  8. 8.
    Cohen, H. and Goldberg, C. Effect of physical exercise on alimentary lipaemia. Brit. Med. J. 2: 500–511, 1960.Google Scholar
  9. 9.
    Master, A.M. The role of effort and occupation (including physicians) in coronary occlusion. J.A.M.A. 174: 942–948, 1960.PubMedCrossRefGoogle Scholar
  10. 10.
    Spain, D.M. and Bradess, V.A. Occupational physical activity and the degree of coronary atherosclerosis in “normal” men. A post-mortem study. Circulation. 22: 239–242, 1960.PubMedGoogle Scholar
  11. 11.
    Keeney, C.E., and Laramie, D.W.: Effect of exercise on blood coagulation. Circ. Res. 10: 691–695, 1962.PubMedGoogle Scholar
  12. 12.
    Latridis, S.G. and Fergusson, J.H. Effect of physical exercise on blood clotting and fibrinolysis. J. Appl. Physiol. 18: 337–344, 1963.Google Scholar
  13. 13.
    Brown, G.W., Huang, T.G., Bortz, E.L. and McGay, C.M. Observations on blood vessels and exercise. J. Geront. 11: 292–297, 1956.PubMedGoogle Scholar
  14. 14.
    Wissler, R.W., Moskowitz, M.S., Hughes, R.H. and Petrie, L.G. A study of the histogenesis of atherosclerosis in man. Circulation 18: 497, 1958.Google Scholar
  15. 15.
    Skold, B.H., Getty, R. and Ramsey, F.K.: Spontaneous atherosclerosis in the arterial system of aging swine. Am. J. Vet, Res. 27: 257–273, 1966.Google Scholar
  16. 16.
    Reiser, R., Sorrels, H.F. and Williams, M.C.: Influence of high levels of dietary fats and cholesterol on atherosclerosis and lipid distribution in swine. Circ. Res. 3: 833–846, 1959.Google Scholar
  17. 17.
    Sperry, W.M. and Webb, M. A revision of the Schoenheimer- Sperry method for cholesterol determination. J. Biol. Chem. 187: 97–106, 1950.PubMedGoogle Scholar
  18. 18.
    Van Handel, E. Suggested modifications of the micro-determination of triglycerides. Clin. Chem. 7: 249–251, 1961.Google Scholar
  19. 19.
    Sperry, W.M. and Brand, F.C. The determination of total lipids in blood serum. J. Biol. Chem. 213: 69–76, 1955.PubMedGoogle Scholar
  20. 20.
    Quick, A.J. Hemorrhagic diseases. Lea and Febiger, Philadelphia, Pennsylvania, 1957.Google Scholar
  21. 21.
    Holman, R.L., McGill, H.C., Strong, J.P. and Geer, J.C. Technics for studying atherosclerotic lesions. Lab. Invest. 7: 42–47, 1958.PubMedGoogle Scholar
  22. 22.
    Holman, R.L., Brown, B.W., Gore, I., McMillan, G.C., Paterson, J.C., Pollak, O.J., Roberts, J.C., and Wissler, R.W. An index for the evaluation of arteriosclerotic lesions in the abdominal aorta. A report by the committee on lesions of the American Society for the Study of Arteriosclerosis. Circulation. 22: 1137–1141, 1960.Google Scholar
  23. 23.
    Guidry, M.A. and Wu, W.T. Suppression of experimental atherosclerosis in dogs by dietary linoleic acid. Proc. Soc. Exp. Biol. Med. 124: 973–976, 1967.PubMedGoogle Scholar
  24. 24.
    Renaud, S. Prevention by methionine feeding of atherosclerosis and thrombosis in hyperlipemia rats. Proc. Soc. Exp. Biol. Med. 121: 452–455, 1966.Google Scholar
  25. 25.
    Naughton, J. and Balke, B. Physical working capacity in medical personnel and the response of serum cholesterol to acute exercise and to training. Amer. J. Med. Sci. 247: 286–292, 1964.PubMedCrossRefGoogle Scholar
  26. 26.
    Campbell, D.E. and Lumsden, T.B. Serum cholesterol concentration during physical training and during subsequent detraining. Amer. J. Med. Sci. 253: 155–162, 19Google Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Roger P. Link
    • 1
    • 2
    • 3
  • Waldir M. Pedersoli
    • 1
    • 2
    • 3
  • Alvin H. Safanie
    • 1
    • 2
    • 3
  1. 1.Department of Physiology, College of Veterinary MedicineUniversity of IllinoisUrbanaUSA
  2. 2.Department of Pharmacology, College of Veterinary MedicineUniversity of IllinoisUrbanaUSA
  3. 3.Illinois Agricultural Experiment StationUrbanaUSA

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