Effect of Exercise on Development of Atherosclerosis in Swine
Few clinical problems in medicine are more beclouded than the relationship between physicial activity and atherosclerosis (1). It has been difficult to evaluate the relationship between exercise and atherosclerosis because of lack of uniformity of conditions under which data have been obtained. Morris et al (2), in a study of 31,000 men ages 35 to 64, found those in occupations requiring physical activity had a lower incidence of heart disease in middle age than those in sedentary occupations. It has been demonstrated in a small sampling of human subjects that doubling the caloric intake of young men did not increase the serum lipoproteins and cholesterol concentrations as long as the surplus energy was expended as heat and muscular energy. Accretion of the excess energy as adipose tissue was accompanied by increase in serum lipids in 67 per cent of the subjects (3). A study of the occurrence of sudden death from coronary atherosclerosis and its relationship with age, sex, race, alcohol consumption and physical activity revealed that strenuous activity was infrequently associated with acute coronary occlusion immediately preceding death (4).
KeywordsTotal Lipid Serum Cholesterol Basilar Artery Coronary Atherosclerosis Fatty Streak
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