Alteration of Renin Release by Stress and Adrenergic Receptor and Related Drugs in Unanesthetized Rats
Appropriate physiologic responses of serum renin activity (SRA) in the unanesthetized rat (1) suggest this highly useful laboratory animal for pharmacologic studies of renin release. Adrenergic mediation of renin release has been suggested by results of previous investigations in man (2—4), anesthetized animals (5—11) and in vitro studies (12). Anesthesia induces renin release which can explain previously reported unique qualities of the rat renin-angiotensin-aldosterone systems (1). As a component of the development of model systems, for study of renin release, we have systematically evaluated the effects of adrenergic agonist and blocking drugs and ganglionic blocking and vasodilating agents on SRA in vivo in the unanesthetized rat. We then extended the investigations to determine the effects of beta-adrenergic blockade on renin release induced by diet and the stresses of anesthesia and swimming exercise.
KeywordsAngiotensin Norepinephrine Epinephrine Catecholamine Propranolol
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