Determinants of Coronary Flow and Myocardial Metabolism in the Newborn Lamb. Influences of Hypoxia and Acidosis

  • S. Evans Downing
  • John C. Lee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 241)


Coronary blood flow and myocardial metabolism are subjects which have received intensive investigative interest since early in the present century (1). This work has been confined largely to the adults of many species, including man, while scant attention has been given to these problems in the newborn. In the early neonatal period there are major changes in cardiac output (2), in the distribution of blood flow (3) and in pressure relations within the various vascular compartments (4) associated with the transition to extrauterine life. Some of these changes may be reflected in the heart by a revision in the ratio of right to left ventricular weight from near unity at birth to one in which the left ventricle may weigh more than twice as much as the right at two to four weeks of age. Active myocardial growth is reflected in a remarkable increase in RNA synthetic processes which are most pronounced in the left ventricular myocardium (5).


Cardiac Output Coronary Sinus Coronary Flow Coronary Blood Flow Aortic Pressure 
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  1. 1.
    Evans, C.L. and Matsuoka, Y.: The effect of various mechanical conditions on the gaseous metabolism and efficiency of the mammalian heart. Am. J. Physiol. 49: 378, 1915.Google Scholar
  2. 2.
    Cross, K.W., Dawes, G.S. and Mott, J.C.: Anoxia, oxygen consumption and cardiac output in new-born lambs and adult sheep. J. Physiol. 146: 316, 1959.PubMedGoogle Scholar
  3. 3.
    Rudolph, A.M. and Heymann, M.A.: Methods for studying distribution of blood flow, cardiac output and organ blood flow. Circ. Research, 21: 163, 1967.Google Scholar
  4. 4.
    Dawes, G.S.: Foetal and Neonatal Physiology. Year Book Med. Pub., Chicago, p. 162, 1968.Google Scholar
  5. 5.
    Gluck, L., Talner, N.S., Stern, H. Gardner, T.H. and Kulovich, M.V.: Experimental cardiac hypertrophy: Concentrations of RNA in the ventricles. Science 144: 1244, 1964.PubMedCrossRefGoogle Scholar
  6. 6.
    Downing, S.E., Talner, N.S., Campbell, A.G.M., Halloran, K.H. and Wax, H.B.: Influence of sympathetic nerve stimulation on ventricular function in the newborn lamb. Circ. Research 25: 417, 1969.Google Scholar
  7. 7.
    Roughton, F.J.W. and Scholander, P.F.: Micro gasometric estimation of the blood gases. J. Biol. Chem. 148: 541, 1943.Google Scholar
  8. 8.
    Barker, S.B. and Summerson, W.H.: The colorimetric deter¬mination of lactic acid in biological material. J. Biol. Chem. 138: 535, 1941.Google Scholar
  9. 9.
    Friedman, T. and Haugen, G.E.: Pyruvate acid: Determination of keto acids in blood and urine. J. Biol. Chem. 147: 415, 1943.Google Scholar
  10. 10.
    Altman, P.L. and Dittmer, D.S.: Respiration and Circulation. Federation of American Societies for Experimental Biology. Bethesda, Maryland, 232, 1971.Google Scholar
  11. 11.
    Rudolph, A.M.: The changes in the circulation after birth: Their importance in congenital heart disease. Circulation 41: 343, 1970.PubMedGoogle Scholar
  12. 12.
    Patten, B.M.: The changes in circulation following birth. Am. Heart J. 6: 192, 1930.CrossRefGoogle Scholar
  13. 13.
    Starling, E.H. and Visscher, M.B.: The regulation of the energy output of the heart. J. Physiol (London) 62: 243, 1926.Google Scholar
  14. 14.
    Braunwald, E., Sarnoff, S.J., Case, R.B., Stainsby, W.N. and Welch, G.H., Jr.: Hemodynamic determinants of coronary flow; Effect of changes in aortic pressure and cardiac output on the relationship between myocardial oxygen consumption and coronary flow. Am. J. Physiol. 192 (3): 157, 1958.PubMedGoogle Scholar
  15. 15.
    Braunwald, E.: The determinants of myocardial oxygen con¬sumption. The Physiologist, 12: 65, 1969.PubMedGoogle Scholar
  16. 16.
    Sonnenblick, E.H., Ross, J., Jr., Covell,J.W., Kaiser, G.A. and Braunwald, E.: Velocity of contraction as a determinant of myocardial oxygen consumption. Am. J. Physiol. 209: 919, 1965.PubMedGoogle Scholar
  17. 17.
    Sonnenblick, E.H., Ross, J., Jr., and Braunwald, E.: Oxygen consumption of the heart. Newer concepts of its multifactoral determination. Am. J. Cardiol. 22: 328, 1968.PubMedCrossRefGoogle Scholar
  18. 18.
    Allella, A., Williams, F.L., Bolene-Williams, C. and Katz, L. N.: Inter-relation between cardiac oxygen consumption and coronary blood flow. Am. J. Physiol. 185: 570, 1955.Google Scholar
  19. 19.
    Case, R.B., Berglund, E. and Sarnoff, S.J.: Ventricular function. VII. Changes in coronary resistance and ventricular function resulting from acutely induced anemia and the effect thereon of coronary stenosis. Am. J. Med. 18: 397, 1955.PubMedCrossRefGoogle Scholar
  20. 20.
    Messer, J.V. and Niell, W.A.: The oxygen supply of the heart. Am. J. Cardiol. 9: 384, 1962.PubMedCrossRefGoogle Scholar
  21. 21.
    Downing, S.E., Gardner, T.H. and Rocamora, J.M.: Adrenergic support of cardiac function during hypoxia in the newborn lamb. Am. J. Physiol. 217: 728, 1969.PubMedGoogle Scholar
  22. 22.
    Henderson, A.H., Parmley, W.W. and Sonnenblick, E.H.: The series elasticity of heart muscle during hypoxia. Cardiovascular Research, 5: 10, 1971.PubMedCrossRefGoogle Scholar
  23. 23.
    Schever, J.: Myocardial metabolism in cardiac hypoxia. Am. J. Cardiol. 19: 385, 1967.CrossRefGoogle Scholar
  24. 24.
    Berne, R.M., Blackman, J.R. and Gardner, T.H.: Hypoxemia and coronary blood flow. J. Clin. Invest. 36: 1101, 1957.PubMedCrossRefGoogle Scholar
  25. 25.
    Utter, M.F.: The role of CO2 fixation in carbohydrate utilization and synthesis. Annals of the New York Acad. Sci. 72: 451, 1959.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • S. Evans Downing
    • 1
  • John C. Lee
    • 1
  1. 1.Department of PathologyYale University School of MedicineNew HavenUSA

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