Structural Alterations of the Myocardium Induced by Chronic Work Overload

  • Sanford P. Bishop
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 241)


When the heart is subjected to a stress which produces an increased work load, which may be either volume or pressure overload, the usual response of the otherwise normal myocardium is an increase in mass. Cardiac enlargement is generally considered to be due to an increase in cell size, that is, hypertrophy, rather than to an increase in cell number, or hyperplasia. Linzbach (34) has proposed, however, based on morphometric studies of hypertrophied human hearts, that when a certain critical size is reached, then cellular hyperplasia occurs. This hypothesis has not been adequately tested in experimental animals since the presently available models for production of hypertrophy seldom produce even a twofold increase in myocardial mass, the critical size of Linzbach. With cellular hypertrophy, however, there is an increased number of organelles, implying that there has been an “organelle hyperplasia” (25).


Congestive Heart Failure Cardiac Hypertrophy Myocardial Hypertrophy Purkinje Fiber Intercalate Disc 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Sanford P. Bishop
    • 1
  1. 1.Department of PathologyOhio State UniversityColumbusUSA

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