The Effects of Hemorrhagic Shock on the Heart

  • Donald B. Hackel
  • N. B. Ratliff
  • E. Mikat
  • T. Graham
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 241)


It has become abundantly clear that shock produced by hemorrhage, as well as by other means, is a multisystem disease involving cells of many organs (1). It is apparent, therefore, that no one organ system need be implicated as the “weak link” which, if strengthened, would prevent irreversibility after transfusion since there are many alternative vicious cycles that can lead to death. However, it is our contention that the heart is significantly damaged during the course of a shock episode, and that this damage is severe enough to lead to a functional defect. There is impressive physiologic and anatomic evidence that this probably is a major contributing factor to irreversibility in most instances.


Hemorrhagic Shock Myocardial Contractility Hypovolemic Shock Sympathetic Stimulation Contractile Element 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Donald B. Hackel
    • 1
  • N. B. Ratliff
    • 1
  • E. Mikat
    • 1
  • T. Graham
    • 1
  1. 1.Department of PathologyDuke University Medical CenterDurhamUSA

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