Effects of Hypertension and Hypoxemia on Arterial Metabolism and Structure

  • D. H. Will
  • C. H. Frith
  • I. F. McMurtry
  • D. J. MacCarter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 241)


Current theories implicate both hypertension and arterial wall hypoxia in the pathogenesis of atherosclerosis. It is generally agreed that hypertension potentiates the development of atherosclerosis although the exact mechanism of this effect remains unknown. Since this condition has been found to have little or no influence on blood lipids (1) attention has been focused principally on the metabolic and morphological effects of the increased pressure on the artery wall itself. Thickening and other structural changes in the arterial walls are well known effects of hypertension; its influence on artery wall metabolism is less well defined. Hypoxemia has been shown to increase arterial wall lipids (2,3). It is unclear, however, whether this is due to in situ synthesis of the lipid or to an imbalance between its arterial wall influx and efflux.


Pulmonary Artery Arterial Wall Abdominal Aorta Thoracic Aorta Left Renal Artery 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • D. H. Will
    • 1
  • C. H. Frith
    • 1
  • I. F. McMurtry
    • 1
  • D. J. MacCarter
    • 1
  1. 1.Department of Physiology and Biophysics College of Veterinary Medicine and Biomedical SciencesColorado State UniversityFort CollinsUSA

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