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Comparative Pathophysiology of Circulatory Disturbances pp 185–203Cite as

Effects of Hypertension and Hypoxemia on Arterial Metabolism and Structure

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 22))

Abstract

Current theories implicate both hypertension and arterial wall hypoxia in the pathogenesis of atherosclerosis. It is generally agreed that hypertension potentiates the development of atherosclerosis although the exact mechanism of this effect remains unknown. Since this condition has been found to have little or no influence on blood lipids (1) attention has been focused principally on the metabolic and morphological effects of the increased pressure on the artery wall itself. Thickening and other structural changes in the arterial walls are well known effects of hypertension; its influence on artery wall metabolism is less well defined. Hypoxemia has been shown to increase arterial wall lipids (2,3). It is unclear, however, whether this is due to in situ synthesis of the lipid or to an imbalance between its arterial wall influx and efflux.

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Author information

Authors and Affiliations

  1. Department of Physiology and Biophysics College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, 80521, USA

    D. H. Will, C. H. Frith, I. F. McMurtry & D. J. MacCarter

Authors
  1. D. H. Will
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  2. C. H. Frith
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  3. I. F. McMurtry
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  4. D. J. MacCarter
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Editor information

Editors and Affiliations

  1. Department of Pathology, University of California at San Diego, La Jolla, California, USA

    Colin M. Bloor

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© 1972 Plenum Press, New York

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Will, D.H., Frith, C.H., McMurtry, I.F., MacCarter, D.J. (1972). Effects of Hypertension and Hypoxemia on Arterial Metabolism and Structure. In: Bloor, C.M. (eds) Comparative Pathophysiology of Circulatory Disturbances. Advances in Experimental Medicine and Biology, vol 22. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-3213-8_12

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  • DOI: https://doi.org/10.1007/978-1-4684-3213-8_12

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-3215-2

  • Online ISBN: 978-1-4684-3213-8

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