Viral Arteritis of Horses

  • T. B. Crawford
  • J. B. Henson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 241)


Although acute vasculitis is an important part of a number of human and animal diseases, the etiology and pathophysiological consequences of these lesions are not well understood. More knowledge about the incitors and effects of acute damage to blood vessels is needed to facilitate the understanding, prevention, and treatment of peripheral vascular disease. Recent work has begun to reveal some of the stimuli which damage blood vessels and the ways in which the vessels respond to them. We have been studying the pathogenesis of equine viral arteritis (EVA), a viral disease of the horse which causes a fulminant generalized vasculitis (1, 2). Results of these studies show how the virus induces injury to the vessels and shed some light on the pathophysiologic effects of acute vascular damage in the horse.


Peripheral Vascular Disease Vascular Lesion Viral Antigen Vascular Damage Equine Infectious Anemia Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Jones, T.C., E.R. Doll, and J.B. Bryans.: The lesions of equine viral arteritis. Cornell Vet. 47: 52, 1957.PubMedGoogle Scholar
  2. 2.
    Crawford, T.B.: Generalized viral induced vasculitis in the horse. Fed. Proc. 28: 685, 1969.Google Scholar
  3. 3.
    Crawford, T.B., J.B. Henson, and J.R. Gorham: Manuscripts in preparation.Google Scholar
  4. 4.
    Cochrane, C.G., and D. Hawkins: Studies on circulating immune complexes. III. Factors governing the ability of circulating complexes to localize in blood vessels. J. Exp. Med. 127: 137, 1968.PubMedCrossRefGoogle Scholar
  5. 5.
    Kniker, W.T. and C.G. Cochrane: Pathogenic factors in vascular lesions of experimental serum sickness. J. Exp. Med. 122: 1, 1965.CrossRefGoogle Scholar
  6. 6.
    Jellinek, H. The role of the elastic membrane in the development of the two forms of vascular fibrinoid. Angiology 21: 636, 1970.PubMedCrossRefGoogle Scholar
  7. 7.
    Jorgenson, L., T. Hovig, H.C. Rowsell, and J.F. Mustard: Adenosine diphosphate-induced platelet aggregation and vascular injury in swine and rabbits. Amer. J. Path. 61: 2, 1970.Google Scholar
  8. 8.
    Jellinek, H., G. Gabor, F. Solti, and B. Veress: The problem of the coronary changes due to disturbance of vascular wall permeability. Angiology 18: 179, 1967.PubMedCrossRefGoogle Scholar
  9. 9.
    Bang, F.B., and C.N. Luttrell: Factors in the pathogenesis of virus disease. Adv. Virus Res. 8: 199, 1961.PubMedCrossRefGoogle Scholar
  10. 10.
    Albrecht, P.Pathogenesis of neutrotropic arbovirus infections. Current Topics in Microbiol. 43: 44, 1968.CrossRefGoogle Scholar
  11. 11.
    Henson, J.B., J.R. Gorham, R.W. Leader, and B.M. Wagner: Experimental hypergammaglobulinemia in mink. J. Exp. Med. 116: 357, 1962.PubMedCrossRefGoogle Scholar
  12. 12.
    Henson, J.B., R.W. Leader, J.R. Gorham, and G.A. Padgett: The sequential development of lesions in spontaneous Aleutian disease of mink. Path. Vet. 3: 289, 1966.CrossRefGoogle Scholar
  13. 13.
    Porter, D.D., and A.E. Larsen: Aleutian disease of mink. Infectious virus-antibody complexes in the serum. Proc. Soc. Exp. Biol, Med. 126: 680, 1967.Google Scholar
  14. 14.
    Henson, J.B. and T.B. Crawford: Manuscript in preparation.Google Scholar
  15. 15.
    Gocke, D.J., C. Morgan, M. Lockshin, K. Hsu, S. Bombardieri, and C.L. Christian: Association between polyarteritis and Australia antigen. Lancet, 1970.Google Scholar
  16. 16.
    Wigley, R.D.: The aetiology of polyarteritis nodosa: A review. New Zealand Med. J. 71: 454, 1970.Google Scholar
  17. 17.
    Dreguss, M.N., and L.S. Lombard: Experimental studies in equine infectious anemia. Philadelphia, University of Pennsylvania Press, 1954.Google Scholar
  18. 18.
    McGuire, T.C., T.B. Crawford, and J.B. Henson; Equine infectious anemia: Detection of infectious virus-antibody complexes in serum. J. Immunol. Submitted for publication.Google Scholar
  19. 19.
    Banks, K.L., J.B. Henson, and T.C. McGuire: Immunologically mediated glomerulitis of horses: I. Pathogenesis in persistent infection by equine infectious anemia virus. Lab. Invest. Submitted for publication.Google Scholar
  20. 20.
    Sams, Jr., W.M., D.D. Harville, and R.K. Winklemann: Necrotizing vasculitis associated with lethal reticuloendothelial diseases. Brit. J. Derm. 80: 555, 1968.PubMedCrossRefGoogle Scholar
  21. 21.
    Sinkovics, J.G., F. Gyorkey, and G.W. Thoma: A rapidly fatal case of systemic lupus erythematosus: Structures resembling viral nucleoprotein strands in the kidney and activities of lymphocytes in culture. Texas Rep. Biol. Med. 27: 3, 1969.Google Scholar
  22. 22.
    Ford, D.K: Evidence for an infectious etiology of rheumatoid arthritis. Med. Clin. North America. 52: 673, 1968.Google Scholar
  23. 23.
    Jellinek, H.: Fibrinoid vascular changes showing the same morphologic pattern following induction by various experimental conditions. Angiology 18: 9, 1967.Google Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • T. B. Crawford
    • 1
  • J. B. Henson
    • 1
  1. 1.Department of Veterinary PathologyWashington State UniversityPullmanUSA

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