Prenatal Cardiovascular Adaptation
The causes and the pathogenesis of almost all congenital anomalies of the cardiovascular system are unknown. Most must originate at a time when the complex folding and septation of the original embryonic vascular channels take place, i.e. within the first six weeks of development. While some genetic factors have been implicated (Zetterqvist, 1971) in most cardiovascular anomalies no strictly genetic basis is ascertained. Conversely, maternal environmental disturbances of embryonic development have been cited occasionally as possible causes of defective fetal growth (Douglas, 1958) and the assumption is made that some of these may affect cardiovascular development as well (Uchida and Rowe, 1957).
KeywordsThalidomide Onic Oligohydramnios Polyhydramnios
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