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Hypothesis: A Possible Relationship Between Blood Clotting and the Recognition by the Body of Foreign Particles

  • David J. Wilkins
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 15)

Abstract

The ability of cells to recognize other cells or particles is a general and fundamental problem in biology. It is basic to the survival of protozoa which must differentiate food from non-food and equally basic to the multicellular animal whose integrity depends upon the ability of its component cells to recognize and respond to cells of a similar or dissimilar type (1,2). Almost without exception when foreign particles enter the mammalian blood stream they are recognized and ultimately ingested by phagocytic cells. This is true whether the particles are parasites which enter the body accidentally, or vaccines or test materials which are introduced deliberately. The ability to distinguish aged, damaged or effete isologous cells from normal cells and the ability to recognize, or not, normal as opposed to neoplastic cells is undoubtedly part of the same phenomenon.

Keywords

Foreign Particle Multicellular Animal Foreign Surface Kuppfer Cell Dissimilar Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • David J. Wilkins
    • 1
  1. 1.Battelle InstituteCarouge-GenevaSwitzerland

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