Chemotaxis of Phagocytes
Chemotaxis has been defined as a reaction by which the direction of locomotion is determined by chemical substances in the environment (1). Chemotactic attraction of leucocytes has first been described by Leber in 1888 and his findings were immediately integrated into Metchnikoff’s contemporary concept of inflammation. It was postulated that chemotaxis directs mobile phagocytes to the site of injury and thereby promotes efficient phagocytosis and histiolysis (2). For a long time the experimental support for this hypothesis remained rather poor (3). More recent data, however, which have been obtained with a new and more efficient in vitro technique developed by Boyden (4) show a fairly good correlation between in vitro chemotaxis and leucocyte accumulation in vivo.
KeywordsHuman Serum Albumin Chemotactic Factor Chemotactic Activity Normal Rabbit Serum Negative Gradient
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