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The Reticuloendothelial System and Immune Phenomena pp 53–58Cite as

Chemotaxis of Phagocytes

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 15))

Abstract

Chemotaxis has been defined as a reaction by which the direction of locomotion is determined by chemical substances in the environment (1). Chemotactic attraction of leucocytes has first been described by Leber in 1888 and his findings were immediately integrated into Metchnikoff’s contemporary concept of inflammation. It was postulated that chemotaxis directs mobile phagocytes to the site of injury and thereby promotes efficient phagocytosis and histiolysis (2). For a long time the experimental support for this hypothesis remained rather poor (3). More recent data, however, which have been obtained with a new and more efficient in vitro technique developed by Boyden (4) show a fairly good correlation between in vitro chemotaxis and leucocyte accumulation in vivo.

This work was supported by the Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung, Grant No. 3.246.69 SR and Hoffmann-La Roche & Co. AG., Basel.

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Author information

Author notes

  1. H. U. Keller

    Present address: Institute of Pathology, University of Bern, CH-3008, Bern, Switzerland

  2. J. F. Borel

    Present address: Biological and Medical Research Division, 881, Sandoz Ltd., CH-4002, Basel, Switzerland

Authors and Affiliations

  1. Schweizerisches Forschungsinstitut, Davos-Platz, Switzerland

    H. U. Keller & J. F. Borel

Authors
  1. H. U. Keller
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  2. J. F. Borel
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Editor information

Editors and Affiliations

  1. Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana, USA

    Nicholas R. Di Luzio

  2. Institute of Biophysics and Radiation Biology, University of Freiburg, Freiburg, Germany

    Kurt B. P. Flemming (Chairman, Sixth International Meeting of the Reticuloendothelial Society) (Chairman, Sixth International Meeting of the Reticuloendothelial Society)

  3. Department of Pharmacology and Radiobiology, Heiligenberg Institute, Heiligenberg, Germany

    Kurt B. P. Flemming (Chairman, Sixth International Meeting of the Reticuloendothelial Society) (Chairman, Sixth International Meeting of the Reticuloendothelial Society)

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© 1971 Plenum Press, New York

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Keller, H.U., Borel, J.F. (1971). Chemotaxis of Phagocytes. In: Di Luzio, N.R., Flemming, K.B.P. (eds) The Reticuloendothelial System and Immune Phenomena. Advances in Experimental Medicine and Biology, vol 15. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3204-6_6

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  • DOI: https://doi.org/10.1007/978-1-4684-3204-6_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3206-0

  • Online ISBN: 978-1-4684-3204-6

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