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Tumour Growth in Relation to the Immunological Environment

  • Chapter
The Reticuloendothelial System and Immune Phenomena

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 15))

Abstract

Malignant change in somatic cell populations may be a relatively common event (1) but the subsequent development of tumours may usually be prevented by the operation of immunological surveillance mechanisms (2,3). The immunological environment of the host may thus play an important role in the regulation of tumour growth and metastasis. Attempts to utilize immunotherapy to control the growth of tumours have, however, been unsuccessful (4,5), although recent attempts to stimulate host responses have achieved an encouraging degree of success (6,7). This has emphasized the urgent need for precise information about the immunological mechanisms and the cell populations which may influence tumour growth. We have been accumulating such information in a series of experiments in which factors affecting the growth of implants of a spontaneous murine mammary adenocarcinoma have been analysed (8,9).

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References

  1. Rosenau, W. and H.D. Moon, Cancer Res., 27: 1973, 1967.

    PubMed  CAS  Google Scholar 

  2. Burnet, F.M., Br. med. Bull., 20: 154, 1964.

    PubMed  CAS  Google Scholar 

  3. Humphrey, J.H. and R.C. White, “Immunology for Students of Medicine”, 3rd ed., London: Blackwell Scientific Publications, p 585, 1970.

    Google Scholar 

  4. Woodruff, M.F.A. and M.O. Symes, Br. J. Cancer, 16: 707, 1962.

    Article  PubMed  CAS  Google Scholar 

  5. Tech. Rep. Ser. Wld Hlth Org., “Immunotherapy of Cancer”, 344, 1966.

    Google Scholar 

  6. Mathé, G., P. Pouillart and F. Lapeyraque, Br. J. Cancer, 23: 814, 1969.

    Article  PubMed  Google Scholar 

  7. Mathé, G., J.L. Amiel, L. Schwarzenberg and M. Schneider, abstract 6th International Meeting of the Reticuloendothelial Society, Freiburg, 1970.

    Google Scholar 

  8. Riches, A.C. and D. Brynmor Thomas, Radiat. Res., 44: 87, 1970.

    Article  PubMed  CAS  Google Scholar 

  9. Riches, A.C. and D. Brynmor Thomas, Br. J. Cancer, (in press).

    Google Scholar 

  10. Riches, A.C., University of Birmingham Ph.D. thesis, 1970.

    Google Scholar 

  11. Dempster, W.J., B. Lennox and J.W. Boag, Br. J. exp. Path., 31: 670, 1950.

    CAS  Google Scholar 

  12. Brent, L. and P.B. Medawar, Proc. R. Soc. London B, 165: 413, 1966.

    Article  CAS  Google Scholar 

  13. Tyan, M.L. and L.J. Cole, Transplantation, 1: 365, 1963.

    Article  PubMed  CAS  Google Scholar 

  14. Globerson, A. and M. Feldman, J. natn. Cancer Inst., 32: 1229, 1964.

    CAS  Google Scholar 

  15. Jooste, S.V., E.M. Lance, R.H. Levey, P.B. Medawar, M. Ruszkiewicz, R. Sharman and R.N. Taub, Immunology 15: 697, 1968.

    PubMed  CAS  Google Scholar 

  16. Levey, R.H. and P.B. Medawar, Proc. natn. Acad. Sci. U.S.A., 56: 1130, 1966.

    Article  CAS  Google Scholar 

  17. Riches, A.C. and D. Brynmor Thomas, J. Anat., 107: 392, 1970.

    Google Scholar 

  18. Ford, C.E., J.L. Hamerton, D.W.H. Barnes and J.F. Loutit, Nature Lond., 177: 452, 1956.

    Article  PubMed  CAS  Google Scholar 

  19. Barnes, D.W.H., C.E. Ford, P.L.T. Ilbery, P.C. Koller and J.F. Loutit, J. cell. comp. Physiol, suppl. 1, 50: 123, 1957.

    Article  CAS  Google Scholar 

  20. Ilbery, P.L.T., P.C. Koller and J.F. Loutit, J. natn. Cancer Inst., 20: 1051, 1958.

    CAS  Google Scholar 

  21. Feldman, M. and D. Yaffe, J. natn. Cancer Inst., 23: 109, 1959.

    Google Scholar 

  22. Koller, P.C. and S.M.A. Doak, Int. J. Radiat. Biol. special suppl., 2: 327, 1960.

    Google Scholar 

  23. Nossal, G.J.V., Australas. Ann. Med., 14: 321, 1965.

    PubMed  CAS  Google Scholar 

  24. Albright, J.F. and T. Makinodan, In “Molecular and Cellular Basis of Antibody Formation”, Ed. by J. Sterzl, Prague, Czechoslovak Academy of Sciences Press, p 427, 1965.

    Google Scholar 

  25. Nettesheim, P., T. Makinodan and M.L. Williams, J. Immun., 99: 150, 1967.

    PubMed  CAS  Google Scholar 

  26. Nettesheim, P. and M.L. Williams, J. Immun., 100: 760, 1968.

    PubMed  CAS  Google Scholar 

  27. Prehn, R.T., Cancer Res., 20: 1614, 1960.

    CAS  Google Scholar 

  28. Riches, A.C. and D. Brynmor Thomas, J. Anat., 106: 180, 1970.

    PubMed  CAS  Google Scholar 

  29. Deodhar, S.D., G. Crile Jr. and P.F. Schofield, Lancet, 1: 168, 1968.

    Article  PubMed  CAS  Google Scholar 

  30. Makinodan, T., M.A. Kastenbaum and W.J. Peterson, J. Immun., 88: 31, 1962.

    PubMed  CAS  Google Scholar 

  31. Makinodan, T. and J.F. Albright, J. cell. comp. Physiol. suppl. 1, 60: 129, 1962.

    Article  CAS  Google Scholar 

  32. Makinodan, T., J.F. Albright, E.H. Perkins and P. Nettesheim, Med. Clins N Am., 49: 1569, 1965.

    CAS  Google Scholar 

  33. Cerilli, G.J. and R.C. Treat, Transplantation, 8: 774, 1969.

    CAS  Google Scholar 

  34. Balner, H. and H. Dersjant, Nature Lond., 224: 376, 1969.

    Article  PubMed  CAS  Google Scholar 

  35. Allison, A.C., L.D. Berman and R.H. Levey, Nature Lond., 215: 185, 1967.

    Article  PubMed  CAS  Google Scholar 

  36. Allison, A.C. and L.W. Law, Proc. Soc. exp. Biol. Med., 127: 207, 1968.

    PubMed  CAS  Google Scholar 

  37. Doll, R. and L. Kinlen, Br. med. J., 4: 420, 1970.

    Article  PubMed  CAS  Google Scholar 

  38. Miller, J.F.A.P., E. Leuchars, A.M. Cross and P. Dukor, Ann. N.Y. Acad. Sci., 120: 205, 1964.

    Article  PubMed  CAS  Google Scholar 

  39. Miller, J.F.A.P., S.M.A. Doak and A.M. Cross, Proc. Soc. exp. Biol. Med., 112: 785, 1963.

    Google Scholar 

  40. Cross, M., E. Leuchars and J.F.A.P. Miller, J. exp. Med., 119: 837, 1964.

    Article  PubMed  CAS  Google Scholar 

  41. Doria, G. and C.C. Congdon, Transplantation Bull., 30: 39, 1962.

    CAS  Google Scholar 

  42. McCulloch, E.A., J.E. Till and L. Siminovitch, Radiat. Res., 24: 482, 1965.

    Article  Google Scholar 

  43. Monaco, A.P., Science, 149: 432, 1965.

    Article  PubMed  CAS  Google Scholar 

  44. Agyris, B.F., J. Immun., 96: 273, 1966.

    Google Scholar 

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Authors and Affiliations

  1. Department of Anatomy, The Medical School, Birmingham, England

    A. C. Riches & D. Brynmor Thomas

Authors
  1. A. C. Riches
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  2. D. Brynmor Thomas
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Editor information

Editors and Affiliations

  1. Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana, USA

    Nicholas R. Di Luzio

  2. Institute of Biophysics and Radiation Biology, University of Freiburg, Freiburg, Germany

    Kurt B. P. Flemming (Chairman, Sixth International Meeting of the Reticuloendothelial Society) (Chairman, Sixth International Meeting of the Reticuloendothelial Society)

  3. Department of Pharmacology and Radiobiology, Heiligenberg Institute, Heiligenberg, Germany

    Kurt B. P. Flemming (Chairman, Sixth International Meeting of the Reticuloendothelial Society) (Chairman, Sixth International Meeting of the Reticuloendothelial Society)

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© 1971 Plenum Press, New York

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Riches, A.C., Thomas, D.B. (1971). Tumour Growth in Relation to the Immunological Environment. In: Di Luzio, N.R., Flemming, K.B.P. (eds) The Reticuloendothelial System and Immune Phenomena. Advances in Experimental Medicine and Biology, vol 15. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3204-6_36

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  • DOI: https://doi.org/10.1007/978-1-4684-3204-6_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3206-0

  • Online ISBN: 978-1-4684-3204-6

  • eBook Packages: Springer Book Archive

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