Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 15)
The Behaviour of Macrophages in Lung Cultures after Exposure to Cigarette Smoke. Evidence for Selective Inhibition by Particulate Matter and Stimulation by the Gas Phase of Cell Metabolism of Alveolar Macrophages
In contrast to the extensive experimental work on the biological activity of cigarette smoke condensates or extracts, there are few experimental investigations concerned with the biological effects of fresh native cigarette smoke itself on animals, tissues or cells. Data obtained with fresh cigarette smoke would appear to be more directly related to the important problem of the role of cigarette smoking in the genesis of pathologic changes in humans than data obtained with cigarette smoke condensates or extracts. For a number of years, therefore, we have used two types of model systems:
Inhalation studies in mice with fresh cigarette smoke (1,2).
Exposure of mouse cell, tissue and organ cultures to puffs of fresh cigarette smoke (3,4,5).
KeywordsCigarette Smoke Alveolar Macrophage Activate Charcoal Epithelioid Cell Golden Hamster
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© Plenum Press, New York 1971