Protective Effect of Reticuloendothelial System Stimulants in Combination with Chloroquine on PlasmodiumBerghei Infection in Mice
The importance of the reticuloendothelial system (RES) in the case of protozoan infections and particularly in malaria has long been recognized but never fully demonstrated. Recently, it was shown that stimulation of the RES alone is unable to increase resistance in mice against Plasmodium berghei infection.
Based on an assumption expressed earlier that the therapeutic effect of antimalarial drugs is not only directed against the malarial parasites but also requires participation of the RES, we attempted to demonstrate this relationship by using a combination of an antimalarial drug (Aralen-chloroquine hydrochloride) and an RES-stimulating agent (cholesteryl oleate, glucan or coenzyme Q10).
The results of these studies show that pretreatment with low doses of chloroquine combined with RES-stimulating agents results in increased survivorship, prolonged survival time and reduced parasitemia in blood-transferred Plasmodium berghei infection in mice. The described effects were strongly dependent on the dose and the time of administration.
KeywordsAntimalarial Drug Reticuloendothelial System Malarial Infection Malarial Parasite Plasmodium Berghei
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