Macrophage Reversal of Anti-Lymphocyte Serum Induced Immunosuppression
The development of organ and tissue transplantation as a relatively common surgical procedure has necessitated the employment of immunosuppressive drug therapy in order to eliminate or delay the onset of immunologically-mediated tissue rejection mechanisms by the recipient (1). A wide variety of immunosuppressives, including antimetabolites, e.g., the purine analogs; alkylating agents, e.g., cyclophosphamide; and specific anticellular sera, e.g., antilymphocyte serum (ALS), have been employed. Unfortunately, a common side effect of nearly all immunosuppressive therapy is the development of post-transplant infections and tumor metastases (2–4). Indeed, Berenbaum (2) reported that up to 30% of renal transplantation failures have been associated with infection, while Starzl and Marchioro (3) have found 50% or more of hepatic transplantation failures to be associated with infections. Similarly, Wilson (4) has claimed that patients subjected to immunosuppressive therapy constitute a high risk group in terms of increased incidence of neoplasia.
KeywordsKupffer Cell Lipid Emulsion Liver Slice Normal Rabbit Serum Methyl Palmitate
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