Antimacrophage Serum: Its Effect on the Immunological Competence and Lymphoid Tissues of the Rat
While macrophages are thought to play a role in immune responses, their precise function has not been clearly defined. It has been suggested that macrophages “trap” antigens during the primary response, process the ingested material (1) and communicate “immunological information” to lymphocytes which initiate antibody formation (2). Macrophages may also destroy target cells, suggesting they have a role in the efferent as well as the afferent arm of the immune response (3). Since antisera raised against macrophages may further delineate the role of the cells in the immune response, this study was undertaken to determine the effects of antimacrophage serum (AMS) on lymphoid tissues and to compare these effects and the effect of AMS on cellular immunological competence with those observed after antilymphocytic serum treatment.
KeywordsLymphoid Tissue Kupffer Cell Thoracic Duct Mixed Lymphocyte Reaction Normal Rabbit Serum
Unable to display preview. Download preview PDF.
- 2.Fishman, M. and F. L. Adler, Cold Spring Harbor Symposium on Quantitative Biology, “Antibodies”, No. 32:343, 1967.Google Scholar
- 3.Pearsall, N. N. and R. S. Weiser, J. Retic. Soc, 5:121, 1968.Google Scholar
- 4.Paul, J., Cell and Tissue Culture, 2nd Edition, Baltimore, Williams and Wilkins Company, p. 207, 1960.Google Scholar
- 5.Reinhardt, W. O. and C. H. Li, Proc. Soc. Exp. Biol. Med., 58:321, 1945.Google Scholar
- 20.Schwarz, M. R., J.R.E.S., 7:146, 1970.Google Scholar
- 21.Seeger, R. C. and J. J. Oppenheim, Fourth Leukocyte Culture Conference, O. R. McIntyre, Ed., Hanover, New Hampshire, 1969.Google Scholar