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The Temporary Sequestration of C3-Coated Red Cells (EC43) in the RES of the Rabbit: A Mechanism for the Non-Lytic Damage of Red Cells by Complement

  • D. L. Brown
  • P. J. Lachmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 15)

Abstract

The removal of inert particulate material or opsonized bacteria and red cells from the circulation at sites in the RES is normally a permanent and irreversible event (l, 2, 3, 4). However, red cells which have fixed complement without proceeding to lysis may be an exception to this rule and complement-coated red cells can under certain conditions undergo only temporary sequestration in the RES. The present report describes a possible mechanism for this temporary sequestration; a mechanism which causes damage to the red cell without lysis and is related to the activity of membrane-bound C3, the third component of complement.

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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • D. L. Brown
    • 1
    • 2
  • P. J. Lachmann
    • 1
    • 2
  1. 1.The Royal Postgraduate Medical SchoolLondonUK
  2. 2.Department of PathologyCambridgeUK

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