Extrinsic Versus Intrinsic, Coagulation-Fibrinolysis: In the Pathophysiology of Shock and Exsanguinating Diatheses

  • Charles L. Schneider
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 9)


Disseminated intravascular coagulation (DIC) can cause circulatory failure and/or depletion of hemostasis. “Reactive” fibrinolysis removes fibrin from vital circulations, occlusions, of which otherwise could be fatal. Inhibitors released during the fibrinolysis (the ICF, or intravascular coagulation-fibrinolysis) can cause anticoagulation, adequate in itself to cause total incoagulability and exsanguinating hemorrhagic diathesis. DICs without, or with lysis (ICF), can be initiated in diverse ways and conditions.


Disseminate Intravascu1ar Coagu1ation Disseminate Intravascular Coagulation Circulatory Failure Hypovolemic Shock Fibrin Degradation Product 
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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Charles L. Schneider
    • 1
  1. 1.Obstetrics & Gynecology Wayne County General HospitalUniversity of MichiganEloiseUSA

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