Treatment of Acute Renal Failure and Chronic Renal Insufficiency with Additional Trasylol Therapy

  • G. Stötter
  • S. Thune
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 9)


Despite improved dialysis techniques, in combination with balanced infusion therapy, early regulation of the water, electrolyte and acid/base metabolism and specific antibiotic therapy, acute renal failure, (ARF) has 29–69 % mortality rates. During the last 1 1/2 years, patients in ARF received in addition to the mentioned standard therapy, Trasylol by continuous drip infusion of usually 1 million KIU in 24 hours. Trasylol inhibits besides trypsin, chymotrypsin, plasmin and the kallikreins which are responsible for the liberation of kinin, as well as leukocytic lysosomal proteinases; these enzyme systems are mainly held responsible for the tubular damage to the kidneys, and in conjunction with oxygen deficiency and other noxae such as bacterial toxins, endogenous poisons and bilirubin, they induce ARF.


Acute Renal Failur Chronic Renal Insufficiency Urinary Tract Obstruction Chronic Pyelonephritis Corrosive Sublimate 
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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • G. Stötter
    • 1
  • S. Thune
    • 1
  1. 1.Medical and Neurological Clinic ICity HospitalsAugsburgGermany

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