Problems of Clinical Research in Shock

  • L. Gallone
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 9)


The vascular pattern of hypovolemia with diminished cardiac output in the early stages of shock syndromes is well recognized and has been extensively studied by many investigators. However, with the development of techniques for rapid performing hemodynamic and respiratory measurements at the bedside, a new range of altered physiologic responses in shock syndromes has been observed. These recently recognized circulatory patterns consist of a hyperkinetic circulation with high cardiac output and rapid mean circulation time in the presence of arterial hypotension and progressive clinical deterioration (Mac — Lean et al. 1965; Khe and Shoemaker 1968; Duff et al. 1969).


Cardiac Output Septic Shock Cardiac Index Central Venous Pressure Septic Shock Patient 
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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • L. Gallone
    • 1
  1. 1.Ospedale Maggiore “Ca’Granda”Istituto di Patologia Speciale ChirurgicaMilanItaly

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