Effect of Varying Blood Sugar Level in Anaphylactic Shock

  • H. L. Dhar
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 9)


Rats and mice are known to be resistant to anaphylactic shock (Gallivallerio, 1910; Longcope, 1922). Procedures used to increase the susceptibility of these species to anaphylactic shock include hypophysectomy (Molomut, 1939), suprarenalectomy (Weiser, Golub & Hamre, 1941), the use of Bordetella pertussis vaccine along with the sensitising dose of antigen (Malkiel & Hargis, 1952) and injection of insulin a shortwhile before challenge (Dhar & Sanyal 1963; Adamkiewicz, Sacra & Ventura, 1964). These procedures have a common factor in the production of hypoglycaemia and as such attempts have been made to analyse the mechanism involved by which alterations in the blood sugar level modify the severity of anaphylactic shock.


Horse Serum Blood Sugar Level Glucose Infusion Pertussis Vaccine Anaphylactic Shock 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Adamkiewicz & Adamkiewicz (1960) Glucose and dextran anaphylactoid Inflammation. Am.J. Physiol. 198; 51.PubMedGoogle Scholar
  2. Adamkiewicz V.W., Sacra P.J. and Ventura J. (1964) Glycemic state and the horse serum and egg-white anaphylactic shock in rats. J. Immunol. 92; 3.PubMedGoogle Scholar
  3. Chakravarty, N. (1962) Aerobic metabolism in anaphylactic reactions in vitro. Am. J. Physiol. 203; 1193.PubMedGoogle Scholar
  4. Dhar, H.L. (1963) Investigations on the mechanism of anaphylaxis Ph.D. Thesis. Calcutta University.Google Scholar
  5. Dhar, H.L. (1969) Comparison of hypoglycaemia induced by horse serum and egg white with B. Pertussis vaccine in rats. Aspt. Allerg. Appl. Immunol.(Press).Google Scholar
  6. Dhar, H.L. and Sanyal, R.K. (1963) Carbohydrate metabolism and anaphylaxis. J. Pharm. Pharmacol. 15; 628.PubMedCrossRefGoogle Scholar
  7. Dhar, H.L., Sanyal, R.K. and West, G.B. (1967a). The relationship of the blood sugar level to the severity of anaphylactic shock Brit. J. Pharmacol. 31; 351.PubMedGoogle Scholar
  8. Dhar, et al (1967b) Anaphylactic shock and the blood sugar level 19; 699.Google Scholar
  9. Dutta, S.N. and Dhar, H.L. (1958). Carbohydrate metabolism and anaphylaxis. Aspt. Allerg. Appl. Immun. 1; 15.Google Scholar
  10. Fishel, C.W. and Szentivanyi A. (1963). The absence of adrenaline induced hyperglycaemia in pertussis-sensitized mice and its relation to histamine and serotonin hypersensitivity. J. Allergy. 34; 439.PubMedCrossRefGoogle Scholar
  11. Galli-Vallerio, B. (1910). Peut-on utiliser Mus rattus et decumann pour 1e diagnostic taches de sang par 1e procédé 1 anaphylaxi. Z. Immun. Forsch. 5; 659.Google Scholar
  12. Kovacs, E.M. and Suffiad, K. (1968). Histamine release by cortisone induced hyperglycaemia. Brit. J. Pharmacol. 32; 362.Google Scholar
  13. Malkiel, S. and Hargis, B.J. (1952) Anaphylactic shock in pertussis vaccinated mouse. Proc. Soc. Exp. Biol. Med. 80;122.PubMedGoogle Scholar
  14. Molomut, N. (1939). The effect of hypophysectomy on immunity and hypersensitivity in rats with a brief description of the operative technique. J. Immun. 37; 113.Google Scholar
  15. Parfentjev, I.A. and Schleyer, W.L. (1949). Influence of histamine on blood sugar level of normal and sensitized mice. Arch. Biochem. 20; 341.PubMedGoogle Scholar
  16. Sanyal, R.K. and West G.B. (1968) Anaphylactic shock in the albino rat. J. Physiol. 142; 571.Google Scholar
  17. Weiser, R.S., Golub O.J. and Hamre, D.M. (1941). Studies on anaphylaxis in the mouse. J. infect. Dis. 68; 97.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • H. L. Dhar
    • 1
  1. 1.Dept. of PharmacologyJawaharlal Institute of Postgraduate Med. Education & Res.PondicherryIndia

Personalised recommendations