Pathophysiologic Mechanisms in Endotoxin Shock and its Therapeutic Approaches
In comparative shock studies, one of the main problems is to find a parameter suitable for measuring the extent of organ damage during shock. Measuring the arterial, central venous and right ventricular pressure only yields very unreliable parameters, as f.i. even with an extremely diminished cardiac output, the arterial blood pressure may, as a compensatory mechanism, be raised above normal. The characteristic common to all forms of shock, regardless of their causative factor, is the acute insufficient blood flow in the circulation periphery. The limiting factor in shock is the insufficient oxygen supply of organs, which results in anaerobic metabolism with all its well-known metabolic consequences (1, 2). The continuous registration of the cardiac output, however, is rather intricate, and up to know has been mainly used in animal experiments. Besides, measuring the cardiac output without simultaneously measuring arterial and central venous blood gases, would not permit a quantitative conclusion as to the oxygen supply of the circulation periphery.
KeywordsOxygen Uptake Arterial Blood Pressure Pulmonary Circulation Platelet Aggregate Fibrinolytic Therapy
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