The Generation of Kinins in the Circulation of the Dog During Hypotension Due to Blood Loss
Many authors have suggested that kinins circulate in the blood of shocked animals (Erdös, 1966). The methods used for measuring kinins have been either indirect, in which kininogen levels have been serially estimated and any reduction taken to infer kinin release (Webster & Clark, 1959) or direct in which lengthy and difficult extraction is required (Brocklehurst & Zeitlin, 1967). Both approaches have disadvantages; they share the limitation inherent in estimating concentrations from intermittently sampled blood, and furthermore neither method necessarily reflects the intrinsic activity of kinins in the animal during shock. The recent observation of Habermann (Symposium on kinins, Fiesole, 1969) that the fall in kininogen level in shock parallels the fall in other plasma proteins, makes the ‘kininogen depletion’ method for kinin estimation especially difficult to interpret.
KeywordsSuperior Mesenteric Vein Portal Blood Pentobarbitone Sodium Kinin Concentration Portal Venous Blood
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