Participation of the Kinin-System in Different Kinds of Shock

  • M. Rocha e Silva
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 9)


The evidences of the participation of the Kinin-system in the etiology of different manifestations of shock derive from the following lines of considerations: a) Activation of proteolytic or esterolytic enzymes in many kinds of shock: anaphylactic, peptone, bacterial toxins, hemorrhagic, scalding (thermic) etc; b) Variations of the bradykininogen (Bkg) content of plasma following the injection of proteases, animal venoms or in different kinds of shock; c) Detection of free kinins in the blood under shock-like conditions; d) Activation of the Kinin-system in in vitro conditions produced by tissue trauma or by the action of shock-producing agents (Ag-Ab, trypsin, animal venoms, cellulose sulfate, and so forth); e) By the use of inhibitors of the kininogenin-kininogen system or by antagonists of the kinin itself.


Hemorrhagic Shock Anaphylactic Shock Active Kinin Cellulose Sulfate Fresh Plasma 


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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • M. Rocha e Silva
    • 1
  1. 1.Department of Pharmacology, Faculty of MedicineU.S.P.Ribeirão, PrêtoBrazil

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