Kinin Formation in the Active Submandibular Salivary Gland
Once upon a time there was a great physiologist, his name was Claude Bernard and he performed experiments on, amongst other things, the submandibular salivary gland. He found that when the nerve to the gland was stimulated, not only was the gland made to secrete, but it also flushed and became warmer (Bernard, 1858). He accordingly proposed that there were three sets of nerve fibres running to this gland: one was secretomotor, the second vasodilator and the third calorigenic. The last was soon forgotten, for there seemed no difficulty in ascribing the increased heat production to the activity associated with secretion; and the same fate might have befallen the vasodilator nerve fibres, were it not for the fact that Heidenhain (1872) showed some years later that atropine could apparently dissociate the two effects, preventing the secretory response to nerve stimulation and leaving a good vasodilator response. We have known since the work of Barcroft (1914), that atropine does not in fact prevent nerve stimulation from increasing the metabolic activity of the gland: this drug has the much more specific effect of abolishing the extrusion of fluid. But by that time Claude Bernard’s view had become the generally accepted one, and the chorda tympani was held to contain vasodilator nerve fibres.
KeywordsSalivary Gland Secretory Activity Capillary Permeability Plasma Kallikrein Locke Solution
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