The Release of Vasopressin by a Direct Central Action of Bradykinin

  • M. Rocha e SilvaJr.
  • M. C. Harris
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)


Bisset and Lewis (1962) reported that prolonged antidiuresis followed the intravenous injection of bradykinin into waterloaded, alcohol anaesthetised rats. The antidiuretic response was always preceded by hypotension and continued for some time after the blood pressure had returned to the pre-injection level. Bisset and Lewis therefore suggested that the antidiuresis may have been caused by antidiuretic hormone (ADH) released as a result of the fall in arterial blood pressure caused by bradykinin.


Arterial Blood Pressure Vertebral Artery Cerebral Circulation Superior Cervical Ganglion Carotid Sinus 


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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • M. Rocha e SilvaJr.
    • 1
    • 2
  • M. C. Harris
    • 1
    • 2
  1. 1.Dept. PhysiologyS.Paulo University Medical SchoolS.PauloBrazil
  2. 2.Dept. Pharmacology, The School of PharmacyLondon UniversityLondonEngland

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