Direct Evidence on the Participation of Bradykinin and Related Kinins in Acute Inflammatory Reactions

  • M. Rocha e Silva
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)


Considerable effort is being spent in our laboratory, to collect some direct evidences of participation of the kinin system in some models of the acute inflammatory reaction. In this work we have the collaboration of many colleagues (2), who should be considered co-workers of this review. Some of them are attending this Symposium and will present their own papers. My task is to present in a condensed form the many evidences we have now of the participation of kinins in the swelling produced in the rat’s paw by moderate heat (45°C), sulfated polymers, such as cellulose sulphate, SN-263, polyvinyl sulfate, polyethylene sulfate, as well as that produced by the well know inflammatogens, carragenin and dextran sulfate. In previous reviews, we have adduced evidences in favor of the participation of the kinin system in shocks produced by prteases, such as trypsin, pronase and nagarse (Rocha e Silva, 1969; Rocha e Silva et al., 1967, 69b).


Dextran Sulfate Mefenamic Acid Sulfated Polysaccharide Acute Inflammatory Reaction Cellulose Sulfate 
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© Plenum Press, New York 1970

Authors and Affiliations

  • M. Rocha e Silva
    • 1
  1. 1.Department of PharmacologyFaculty of Medicine of Ribeirao Preto, U. S. P.Ribeirao PretoBrazil

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