Histamine, Bradykinin and Serotonin Potentiation by the Slow Reacting Substance in Anaphylaxis

  • H. V. Huidobro
  • M. Propker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)


The formation of smooth muscle stimulating substance which causes slow and long-lasting contraction of the guinea-pig ileum, has been found in some animal species and several tissues (Brocklehurst 1960, Rapp 1961, Uvnas 1963). The substance is an unsaturated hydroxylated myotropic fatty acid. Its chemical nature is, however, still unknown.


Anaphylactic Reaction Graphic Purification Slow React Substance Bronchial Spasm Maximal Potentiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Brocklehurst, W. E. (1960), J. Physiol. 151, 416.PubMedGoogle Scholar
  2. Rapp, H. J. (1961), J. Physiol., 158, 35P.Google Scholar
  3. Uvnas, B. (1963) Biochem. Pharmacol., 12, 430.Google Scholar
  4. Konzatt, H. and Rossler, R., (1940), Archiv. Exp. Path. Pharmakol., 195, 71.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • H. V. Huidobro
    • 1
  • M. Propker
    • 1
  1. 1.Department of PharmacologyUniversity of Buenos AiresBuenos AiresArgentina

Personalised recommendations