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Interference of Carrageenin, Non-Steroidal Anti-Inflammatory Drugs and Protease Inhibitors with the Kallikrein-Kinin System

  • B. B. Vargaftig
  • N. Bhargava
  • C. J. de Vos
  • I. L. Bonta
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)

Abstract

Carrageenin has kininogen depleting properties in the rat (1). Its local oedema inducing effects are inhibited by phenylbutazone and other non-steroidal antiinflammatory drugs. The kaolin induced elevation of kinin activity in the rat oedema fluid is also counteracted by phenylbutazone, while this drug is unable to inhibit the polyvinylpyrrolidone induced oedema, where a lack of increased kinin activity was demonstrated (2). In the present work additional support is given to the postulation that the antiinflammatory action of phenylbutazone may partly be due to its interference with the kallikrein-kinin system.

Keywords

Ellagic Acid Anaphylactic Shock Sodium Benzoate Minimum Effective Dose Kinin Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    ROTHSCHILD, A.M., International Symposium on Vaso-active Polypeptides, Bradykinin and related Kinins (Eds. Rocha e Silva, M, and Rothschild, H.A.) P. 197, Edart, São Paulo, 1967.Google Scholar
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    BONTA, I.L., and de VOS, C.J., European J. Pharmacol., 1, 222, 1967.CrossRefGoogle Scholar
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    GRAUTVIK, K.M., and RUGSTAD, H.E., Br. J. Pharmacol., 31, 390, 1967.Google Scholar
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    BHARGAVA, N., BONTA, I.L., (to be published).Google Scholar
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    LECOMTE, J., Comp. Rend. Soc. Biol., 162, 807, 1968.PubMedGoogle Scholar
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    FREY, E.K., KRAUT, H., and WERLE, E., “Das kallikrein-kinin-system und seine inhibitoren” Ferdinand enke Verlag, Stuttgart, P. 57–58, 1968.Google Scholar
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    NARTICOVA, V.F., and PASKHINA, T.S., Biokhimiya, 34, 282, 1969.Google Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • B. B. Vargaftig
    • 1
    • 2
  • N. Bhargava
    • 1
    • 2
  • C. J. de Vos
    • 1
    • 2
  • I. L. Bonta
    • 1
    • 2
  1. 1.Departments of PharmacologyS.A. OrganonEragny-sur-EpteFrance
  2. 2.N.V. OrganonOssThe Netherlands

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