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Kinins and Anti-Inflammatory Drugs

  • H. O. J. Collier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)

Abstract

In 1959, we showed that bradykinin elicits bronchoconstriction in the guinea-pig and that a small dose of aspirin or phenylbutazone abolishes this response to bradykinin, without diminishing the bronchoconstrictor effect of histamine or 5-hydroxytryptamine (1, 2). Several of the properties of this antagonism suggested that it occurred at bradykinin receptors on the smooth muscle (3,4; but when bronchoconstriction induced by the Hounslow preparation of slow-reacting substance in anaphylaxis (SRS-A-H), which acted at different receptors, also proved to be blocked by antiphlogistic acids (5) and when several other paradoxical features of the antagonism emerged, we proposed that aspirin exerted its effect at a point on the route leading to or from the specific receptors (5,6) and later suggested that this might involve the release of an intermediary substance (7). Piper and Vane (8) have now shown that such a mechanism exists in guinea-pig isolated lungs, in that antiphlogistic acids block the release of rabbit-aorta contracting substance. The background and implications of this story are outlined here, with particular reference to kinins. A brief discussion of its bearing on the mode of action of aspirin has already appeared (9).

Keywords

Peritoneal Exudation Antinociceptive Action Potency Ratio Bradykinin Receptor Collier Table 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • H. O. J. Collier
    • 1
  1. 1.Parke-Davis & Co.Hounslow, MiddlesexEngland

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