The Inhibition of Guinea-Pig Plasma Kallikrein by Amidines

  • G. E. Davies
  • J. S. Lowe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)


There are many similarities between trypsin and the plasma kallikreins, e.g.
  1. 1.

    both hydrolyse Noc-substituted esters of lysine and arginine.

  2. 2.

    both are inhibited by di-isopropylphosphofluoridate and soya bean trypsin inhibitor.

  3. 3.

    both release a kinin from kininogen.

  4. 4.

    both cause an increase in vascular permeability on intradermal injection.



Esterase Activity Amino Acid Ester Plasma Kallikrein Mild Burn Imperial Chemical Industry 
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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • G. E. Davies
    • 1
  • J. S. Lowe
    • 1
  1. 1.Pharmaceuticals DivisionImperial Chemical Industries LimitedMacclesfield, CheshireUK

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