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The Inhibition of Guinea-Pig Plasma Kallikrein by Amidines

  • G. E. Davies
  • J. S. Lowe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)

Abstract

There are many similarities between trypsin and the plasma kallikreins, e.g.
  1. 1.

    both hydrolyse Noc-substituted esters of lysine and arginine.

     
  2. 2.

    both are inhibited by di-isopropylphosphofluoridate and soya bean trypsin inhibitor.

     
  3. 3.

    both release a kinin from kininogen.

     
  4. 4.

    both cause an increase in vascular permeability on intradermal injection.

     

Keywords

Esterase Activity Amino Acid Ester Plasma Kallikrein Mild Burn Imperial Chemical Industry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Brandi, C.M.W., Mendes, J., Paiva, A.C.M., & Prado, E.S. (1965). Biochem. Pharmac, 14, 1665.CrossRefGoogle Scholar
  2. Davies, G.E. & Lowe, J.S. (1963). Br. J. Pharmac. Chemother., 21, 491.Google Scholar
  3. Diniz, C.R., Pereira, A.A., Barroso, J., Mares-Guia, M. (1965). Biochem. biophys. Res. Commun., 21, 448.PubMedCrossRefGoogle Scholar
  4. Habermann, E. (1962). Hoppe Zeiler’s Z. physiol. Chem., 328, 15.CrossRefGoogle Scholar
  5. Habermann, E. & Klett, W. (1966). Biochem. Z., 346, 133.PubMedGoogle Scholar
  6. Prado, E.S., Prado, J.L. & Brandi, C.M.W. (1962). Archs int. Pharmacodyn. Ther., 137, 358.Google Scholar
  7. Mares-Guia, M. & Diniz, C.R. (1967). In “International Symposium on Vasco-Active Polypeptides; Bradykinin & Related Kinins.” edited by M. Rocha, E. Silva & H.A. Rothschild. Ribeirao Preto, Sao Paulo, Brazil, p. 149.Google Scholar
  8. Mares-Guia, M. & Shaw, E. (1965). J. biol. Chem., 240, 1579.PubMedGoogle Scholar
  9. Webster, M.E. & Pierce, J.V. (1961). Proc. Soc. exp. Biol. Med., 107, 186.PubMedGoogle Scholar
  10. Werle, E. & Trautschold, I. (1963). Ann. N.Y. Acad. Sci., 104, 117.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • G. E. Davies
    • 1
  • J. S. Lowe
    • 1
  1. 1.Pharmaceuticals DivisionImperial Chemical Industries LimitedMacclesfield, CheshireUK

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