The Antikinin Action of Some Antihistaminic Drugs on the Isolated Guinea-Pig Ileum, Rat Uterus and Blood Pressure of the Anesthetized Dog
In our studies on the action of antihistaminic drugs on the parasympathetic salivation we found that all of these substances — with the exception of mepyramine — inhibited the secretion of the submaxillary gland of the dog (Lorenz et al. 1967, Lorenz and Pfleger 1968). Since some different mediators seem to be involved in the stimulation of the salivary secretion, like acetylcholine, histamine, and kinins (Werle and Lorenz 1966, Lorenz et al. 1968), we studied the specificity of the inhibitory action of the antihistaminic drugs in three different test systems: the isolated guinea pig ileum, the isolated rat uterus and the blood pressure of the anesthetized dog. This paper describes the antikinin activity of these drugs.
KeywordsSubmaxillary Gland Salivary Secretion Tory Action Strong Inhibitory Action Kinin Receptor
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