The Pathophysiological Role of Kallikrein and Histamine in Malaria
The lesions often observed in some organs at the advanced stages of malarial infections include apparent ‘blockage’ of capillaries by parasitised and unparasitised erythrocytes, possibly resulting from the activity of a circulating toxic factor liberated during the infection (Maegraith, 1966). The complicated clinical picture observed in this disease and the relatively irregular correlation involving the clinical and pathological findings with the intensity of the parasitic infection, have stimulated investigation into the physiological and pathological processes such as coma, which might result from the activity of substances liberated during the infection.
KeywordsIntradermal Injection Plasmodium Knowlesi Infected Monkey Kallikrein Activity Knowlesi Malaria
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