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An Electron Microscopic Study of the Vascular Endothelium as a Site for Bradykinin and Adenosine-5′-Triphosphate Inactivation in Rat Lung

  • Una Smith
  • James W. Ryan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)

Abstract

Bradykinin is inactivated in one circulation through the intact or “blood-free rat lung (1). Inactivation of bradykinin occurs by hydrolysis of peptide bonds, yet the effluent of a blood-free lung preparation does not contain sufficient hydrolase activity to account for this extremely rapid and efficient degradation. Furthermore, there is no measurable retention of bradykinin or its peptide fragments by the lung. It seems likely, therefore, that bradykinin is inactivated by cellular enzymes at or near the endothelium of pulmonary blood vessels.

Keywords

Capillary Endothelial Cell Multivesicular Body Capillary Endothelium Capillary Lumen Pinocytotic Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Una Smith
    • 1
  • James W. Ryan
    • 1
  1. 1.Department of MedicineUniversity of Miami School of MedicineMiamiUSA

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