Abstract
Bradykinin is inactivated in one circulation through the intact or “blood-free rat lung (1). Inactivation of bradykinin occurs by hydrolysis of peptide bonds, yet the effluent of a blood-free lung preparation does not contain sufficient hydrolase activity to account for this extremely rapid and efficient degradation. Furthermore, there is no measurable retention of bradykinin or its peptide fragments by the lung. It seems likely, therefore, that bradykinin is inactivated by cellular enzymes at or near the endothelium of pulmonary blood vessels.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ryan, James W., Juan Roblero and John Morrow Stewart. Biochem. J. 110:795–797, 1968.
Marchesi, V. T. and R. J. Barrnett. J. Cell Biol. 17:547, 1965.
Tice, Lois W. and David S. Smith. J. Cell Biol. 25:121–135, 1965.
Tice, L. W. Tissue & Cell 1:97–101, 1969.
Reynolds, E. A. J. Cell Biol. 12:208–212, 1963.
Wachstein, Max and Elizabeth Meisel. Am. J. Clin. Path. 22:13–23, 1957.
De Duve, C. and R. Wattiaux. Ann. Rev. Physiol. 28:435–492, 1966.
Locke, M. and J. V. Collins. J. Cell Biol. 36:453–483, 1968.
Smith, D. S., K. Compher, M. Janners, C. Lipton and L. W. Wittle. J. Morph. 127:41–72, 1969.
Binet, L. and M. Burstein. Presse Medicale 58:1201, 1950.
Palade, G. E. Anat. Record 130:467, 1958.
Palade, G. E. and R. R. Bruns. J. Cell Biol. 37:633–649, 1968.
Porter, K. R. and J. R. Sotelo. J. Biophys. Biochem. Cytol. 5:327–342, 1959.
Cardell, R. R., S. Badenhausen and K. R. Porter. J. Cell Biol. 34:123–155, 1967.
Cushman, D. W. and H. S. Cheung. Fed. Proc. 28:799, 1969, (abstract 3019).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1970 Plenum Press, New York
About this chapter
Cite this chapter
Smith, U., Ryan, J.W. (1970). An Electron Microscopic Study of the Vascular Endothelium as a Site for Bradykinin and Adenosine-5′-Triphosphate Inactivation in Rat Lung. In: Sicuteri, F., e Silva, M.R., Back, N. (eds) Bradykinin and Related Kinins. Advances in Experimental Medicine and Biology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3198-8_31
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3198-8_31
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3200-8
Online ISBN: 978-1-4684-3198-8
eBook Packages: Springer Book Archive