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Liberation Mechanisms of Kinins in Bovine Plasma

  • Tomoji Suzuki
  • Shigeharu Nagasawa
  • Mitsuo Yano
  • Hidenobu Takahashi
  • Hisao Kato
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)

Abstract

Kallikrein is present in mammalian plasma as the inactive form, kallikreinogen. The enzymatic activation of kallikreinogen with trypsin and unfractionated serums has first been shown by WERLE et al. (1955). It is also well known that when whole plasma is treated with acid, casein, acetone or glass powders, kallikreinogen is converted to the active enzyme. In addition to these activations of kallikreinogen, MARGOLIS (i960) has suggested that Hageman factor will be required for the endogeneous activation of the kallikreinogen in plasma, and other workers have considered that this activation proceeds via activation of permeability globulin. This idea is mainly based on the observations of RATNOPF and MILES (1964) that permeability globulin could be activated by Hageman factor and that permeability globulin releases kinin from the unfractionated plasma.

Keywords

Glass Powder Cyanogen Bromide Bovine Plasma Plasma Kallikrein High Molecular Weight Kininogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. DAVIS, B. J., Ann. New York Acad. Sci., 121, Art. 2, 404 (1964)CrossRefGoogle Scholar
  2. GROSS, E. and WITKOP, B., J. Amer. Chem. Soc., 83, 1510 (1961)CrossRefGoogle Scholar
  3. HABERMANN, E. and MüLLER, B., Arch. exp. Path. Pharmak., 253, 444 (1966)Google Scholar
  4. HOCHSTRASER, K. and WERLE, E., Z. physiol. chem., 348, 177 (1967)CrossRefGoogle Scholar
  5. KATO, H. and SUZUKI, T., Biochem. Biophys. Res. Communs., 32, 800 (1968)CrossRefGoogle Scholar
  6. MARGOLIS, J., J. Physiol., 151, 238 (1960)PubMedGoogle Scholar
  7. NAGASAWA, S., Mizushima, Y., Sato, T., Iwanaga, S. and Suzuki, T., J. Biochem., 60, 643 (1966)PubMedGoogle Scholar
  8. NAGASAWA, S., HORIUCHI, K., YANO, M. and SUZUKI, T., J. Biochem., 62, 398 (1967)PubMedGoogle Scholar
  9. NAGASAWA, S., TAKAHASHI, H., KOIDA, M., SUZUKI, T. and SCHOENMAKERS, J. G. G., Biochem. Biophys. Res. Communs., 32, 644 (1968)CrossRefGoogle Scholar
  10. NAGASAWA, S. and SUZUKI, T., J. Biochem., 66, 273 (1969)PubMedGoogle Scholar
  11. RATNOPP, O. D. and MILES, A. A., Brit. J. exp. Path., 45, 328 (1964)Google Scholar
  12. ROBERTS, P. S., J. Biol. Chem., 232, 285 (1958)PubMedGoogle Scholar
  13. SCHOENMAKERS, J. G. G., Matze, R., Haanen, C. and Zilliken, F., Biochem. Biophys. Acta, 101, 166 (1965)PubMedGoogle Scholar
  14. SUZUKI, T., MIZUSHIMA, Y., SATO, T. and IWANAGA, S., J. Biochem., 57, 14 (1965)PubMedGoogle Scholar
  15. SUZUKI, T., IWANAGA, S., NAGASAWA, S. and SATO, T., p.149, Hypotensive Peptides Proceedings of the International Symposium, E. G. Erdös, N. Back, S. Sicuteri (Eds.) (Springer-Verlag, New York, 1966)CrossRefGoogle Scholar
  16. SUZUKI, T., IWANAGA, S., SATO, T., NAGASAWA, S., KATO, H., YANO, M. and HORIUCHI, K., p.27, International Symposium on Vaso-active Polypeptides: Bradykinin and Related Kinins. M. Rocha E Silva and H. A. Rothschild (Eds.) III International Pharmacological Congress and Soc. Bras. Farmacologia & Terapeutica Experimental, São Paulo (1967)Google Scholar
  17. VOGT, W., GARBE, G. and SCHMIDT, G., Arch. exp. Path. u. Pharmak., 256, 127 (1967)Google Scholar
  18. WERLE, E., RORELL, M. M. and MAIER, L., Arch. exp. Path. u. Pharmak., 225, 369 (1955)CrossRefGoogle Scholar
  19. YANO, M., NAGASAWA, S., HORIUCHI, K. and SUZUKI, T., J. Biochem., 62, 504 (1967)PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Tomoji Suzuki
    • 1
  • Shigeharu Nagasawa
    • 1
  • Mitsuo Yano
    • 1
  • Hidenobu Takahashi
    • 1
  • Hisao Kato
    • 1
  1. 1.Division of Plasma Proteins, Institute for Protein ResearchOsaka UniversityOsakaJapan

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