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Effects of Bradykinin, Eledoisin, and Physalaemin on Cardiovascular Dynamics

  • Jiro Nakano
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)

Abstract

Recently, many investigators have studied the cardiovascular effects of the synthetic vasoactive peptides, bradykinin (2–6,12–15, 17, 20–22, 24, 27, 33, 40–44), eledoisin (3, 6, 10, 18, 23, 24, 26, 28–32, 40), and physalaemin (7, 19, 37). It has been well established that, with few exceptions (31, 46), the peptides exert directly a vasodilator action in many species of animals (1, 4–6, 11, 12, 25, 39, 41, 44, 46, 47). Consequently, the peptides appear to cause a variety of hemodynamic changes in the heart and circulation. The present studies were undertaken to investigate the precise effects of synthetic bradykinin, eledoisin and physalaemin on the cardiovascular dynamics and also to elucidate the underlying hemodynamic mechanisms responsible for the effects of these peptides in anesthetized dogs.

Keywords

Pulmonary Arterial Pressure Total Peripheral Resistance Systemic Arterial Pressure Vasodilator Action Right Atrial Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Jiro Nakano
    • 1
  1. 1.Departments of Pharmacology and of MedicineUniversity of Oklahoma School of MedicineOklahoma CityUSA

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