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Observations on Plasma Kinin Forming Enzymes

  • V. Eisen
  • K. L. A. Glanville
  • A. J. Collins
  • H. G. Smith
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)

Abstract

Using various types of chromatography and electrophoresis, Kagen et al (1962) and Webster (1968) found in human serum one kallikrein, Eisen and Glanville (1969) two, and Colman et al (1969) three, of which two may have been a monomer and polymer of the same enzyme. Evidence for a kininogenase differing from the γ-globulin plasma kallikrein was also reported by Armstrong and Mills (1964). Plasma also appears to contain as many as four factors capable of activating the prekallikreins. It is not yet certain how many of these factors form part of a system comparable to the cascade sequence of blood clotting. Most authors present intrinsic plasma kinin formation as a sequence of three pre-enzyme — enzyme transformations. The first step (activation of factor XII) and the third step (activation of plasma kallikrein) are well established. The intermediate enzyme of the second stage may be an activator (PF/Dil.; Mason and Miles, 1962), or both an activator and kininogenase (‘kininogenase II’; Vogt, 1966). Evidence has also been reported that factor XII acts directly on the main kallikrein (Nagasawa et al., 1968), or even directly on kininogen (Rocha e Silva et al., 1967).

Keywords

Human Plasma Heated Plasma Plasma Kallikrein Intermediate Enzyme Cascade Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • V. Eisen
    • 1
  • K. L. A. Glanville
    • 1
  • A. J. Collins
    • 1
  • H. G. Smith
    • 1
  1. 1.Rheumatology Research DepartmentMiddlesex Hospital Medical SchoolLondonUK

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