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Significance of Kinins in The Coronary Circulation

  • E. Bassenge
  • E. Werle
  • P. Walter
  • J. Holtz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)

Abstract

The physiological regulation of coronary flow is still a matter of dispute (Berne 1964, Schaper 1967). It has been speculated that kinins may play a major role in coronary regulation (Parrat 1964, Scholtholt et al. 1965), since they have a powerful action on the coronary system. Four different approaches were made in order to elucidate the significance of the kinin system in coronary regulation:
  1. (a)

    Use of kinin antagonists

     
  2. (b)

    Experimental increase of carboxypeptidase B concentration by constant intracoronary infusion

     
  3. (c)

    Administration of kininase inhibitors

     
  4. (d)

    Perfusion with a kininogen-free red cell suspension in a buffered dextran solution

     

Keywords

Coronary Flow Myocardial Contractility Reactive Hyperemia Coronary Circulation Thioglycolic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • E. Bassenge
    • 1
  • E. Werle
    • 1
  • P. Walter
    • 1
  • J. Holtz
    • 1
  1. 1.Department of Physiology, Department of Clinical Chemistry and Clinical BiochemistryUniversity of MunichGermany

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