Significance of Kinins in The Coronary Circulation

  • E. Bassenge
  • E. Werle
  • P. Walter
  • J. Holtz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)

Abstract

The physiological regulation of coronary flow is still a matter of dispute (Berne 1964, Schaper 1967). It has been speculated that kinins may play a major role in coronary regulation (Parrat 1964, Scholtholt et al. 1965), since they have a powerful action on the coronary system. Four different approaches were made in order to elucidate the significance of the kinin system in coronary regulation:
  1. (a)

    Use of kinin antagonists

     
  2. (b)

    Experimental increase of carboxypeptidase B concentration by constant intracoronary infusion

     
  3. (c)

    Administration of kininase inhibitors

     
  4. (d)

    Perfusion with a kininogen-free red cell suspension in a buffered dextran solution

     

Keywords

Ischemia Heparin Adenosine Bicarbonate Catecholamine 

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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • E. Bassenge
    • 1
  • E. Werle
    • 1
  • P. Walter
    • 1
  • J. Holtz
    • 1
  1. 1.Department of Physiology, Department of Clinical Chemistry and Clinical BiochemistryUniversity of MunichGermany

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