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The Isolation and Partial Characterization of Kinin-Forming Enzymes and Other Active Components From Human Plasma

  • Henry Z. Movat
  • Harold B. Sender
  • Mary P. Treloar
  • Yuko Takeuchi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)

Abstract

Three years ago in Ribeirão Prêto we presented evidence that antigen-antibody (Ag-Ab) precipitates can activate the kinin system if such precipitates are incubated with non-glass contacted guinea pig, rabbit or human serum. Such activated serum acquires the following properties: (a). It enhances vessel permeability when injected intradermally into guinea pigs pretreated with the antihistamine mepyramine. (b). It contracts the rat uterus; a reaction inhibited by carboxypeptidase-B, but not by serotonin antagonists. (c). It has TAME-esterase activity. (d). It enhances the clotting of recalcified plasma. (e). It causes hypotension when injected intravenously. Several serine esterase inhibitors suppress the permeability enhancing activity of Ag-Ab treated serum (6).

Keywords

Heated Plasma Plasma Kallikrein Fresh Plasma Linear Dose Response Starting Buffer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Henry Z. Movat
    • 1
  • Harold B. Sender
    • 1
  • Mary P. Treloar
    • 1
  • Yuko Takeuchi
    • 1
  1. 1.Division of Experimental PathologyUniversity of TorontoTorontoCanada

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