General Features of Metabolic Control as Applied to the Erythrocyte

  • John R. Williamson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 6)


The purpose of this paper is to review the background and principles used to elucidate control mechanisms in multienzyme sequences. Examples are taken from the literature to illustrate the sites of control of erythrocyte glycolysis observed under different conditions, and the possible nature of the control chemicals. Emphasis will be placed on control of the 2,3-diphosphoglycerate (DPG) level in erythrocytes and possible feedback relationships between the concentration of free DPG, as determined by its differential binding to oxy- and deoxyhemoglobin, and the regulation of glycolysis. For a more extensive treatment of erythrocyte glycolysis, the reader is referred to several recent reviews (1–3).


Pyruvate Kinase Adenine Nucleotide Triose Phosphate Isomerase Triose Phosphate Glycolytic Intermediate 
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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • John R. Williamson
    • 1
  1. 1.Johnson Research FoundationUniversity of Penna.PhiladelphiaUSA

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