Studies of Red Cell Glycolysis and Interactions with Carbon Monoxide, Smoking, and Altitude
The exciting story of the functional association between phosphorylated intermediates of the red cell and hemoglobin may be viewed as beginning in 1963 when Chanutin’s laboratory first published data showing that a number of phosphate compounds reacted with hemoglobin to form a complex which had an altered electrophoretic mobility (Sugita and Chanutin, 1963; Chanutin and Curnish, 1964 and 1965). This was followed in 1967 by Chanutin and Curnish’s report that certain of these bound phosphorylated intermediates of the red cell, including 2,3-diphosphoglycerate (DPG) and ATP, affect the oxygen dissociation properties of hemoglobin. In the same year, Benesch and Benesch (1967) reported similar effects. Subsequent observations from a number of laboratories have highlighted the importance of these findings. These developments have given great impetus to the whole area of red cell metabolism and function, and to the study of the interrelationships of the red cell with the rest of the organs of gas transport. In 1968, we (Eaton and Brewer, 1968) reported that a correlation exists between levels of red cell DPG and whole blood hemoglobin levels, suggesting that, contrary to the statements of Benesch et al. (1968), variation of DPG in the physiological range was of significance in oxygen transport. These findings have been confirmed and extended in a number of papers reported at this conference.
KeywordsOxygen Tension Glucose Consumption Arterial Oxygen Tension Oxygen Dissociation Chronic Mountain Sickness
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