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Studies of Red Cell Glycolysis and Interactions with Carbon Monoxide, Smoking, and Altitude

  • George J. Brewer
  • John W. Eaton
  • John V. Weil
  • Robert F. Grover
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 6)

Abstract

The exciting story of the functional association between phosphorylated intermediates of the red cell and hemoglobin may be viewed as beginning in 1963 when Chanutin’s laboratory first published data showing that a number of phosphate compounds reacted with hemoglobin to form a complex which had an altered electrophoretic mobility (Sugita and Chanutin, 1963; Chanutin and Curnish, 1964 and 1965). This was followed in 1967 by Chanutin and Curnish’s report that certain of these bound phosphorylated intermediates of the red cell, including 2,3-diphosphoglycerate (DPG) and ATP, affect the oxygen dissociation properties of hemoglobin. In the same year, Benesch and Benesch (1967) reported similar effects. Subsequent observations from a number of laboratories have highlighted the importance of these findings. These developments have given great impetus to the whole area of red cell metabolism and function, and to the study of the interrelationships of the red cell with the rest of the organs of gas transport. In 1968, we (Eaton and Brewer, 1968) reported that a correlation exists between levels of red cell DPG and whole blood hemoglobin levels, suggesting that, contrary to the statements of Benesch et al. (1968), variation of DPG in the physiological range was of significance in oxygen transport. These findings have been confirmed and extended in a number of papers reported at this conference.

Keywords

Oxygen Tension Glucose Consumption Arterial Oxygen Tension Oxygen Dissociation Chronic Mountain Sickness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • George J. Brewer
    • 1
    • 2
  • John W. Eaton
    • 1
    • 2
  • John V. Weil
    • 1
    • 2
  • Robert F. Grover
    • 1
    • 2
  1. 1.Departments of Human Genetics and Medicine (Simpson Memorial Institute)University of MichiganUSA
  2. 2.Department of MedicineUniversity of ColoradoUSA

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