Depence of Oxyhemoglobin Dissociation and Intraery-Throcytic 2,3-DPG on Acid-Base Status of Blood. II. Clinical and Experimental Studies

  • P. Astrup
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 6)


Since our first report (Astrup, 1969) at a symposium in Uppsala in February 1969 on changes of the oxygen affinity of hemoglobin due to pH-dependent 2,3-DPG changes we have studied this relationship more extensively in patients with acid-base disorders and also in normal individuals with induced changes of the acid-base status of the blood. The results of these investigations will be presented in this paper.


Metabolic Alkalosis Oxygen Affinity Feedback Control System Nium Chloride Standard Bicarbonate 


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  1. Astrup, P. (1969). Forsvarsmedicin. In press.Google Scholar
  2. Astrup, P., Engel, K., Severinghaus, J.W., and Munson, E. (1965). Scand. J. Clin. Lab. Invest. 17:515.PubMedCrossRefGoogle Scholar
  3. Kjeldsen, K., and Damgaard, F. (1968). Scand. J. Clin. Lab. Invest., Suppl. 103, 22:20.Google Scholar
  4. Mulhausen, R.O., Astrup, P., and Mellemgaard, K. (1968). Scand. J. Clin. Lab. Invest., Suppl. 103, 22:9.Google Scholar
  5. Nygaard, S., and Rorth, M. (1969). Scand. J. Clin. Lab. Invest. In press.Google Scholar
  6. Rapoport, S., and Guest, G.M. (1939). J. Biol. Chem. 131:576.Google Scholar
  7. Rorth, M. (1969). This journal, preceding paper.Google Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • P. Astrup
    • 1
  1. 1.RigshospitaletCopenhagenDenmark

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