Variation in 2,3-Diphosphoglycerate and ATP Levels in Human Erythrocytes and Effects on Oxygen Transport

  • John W. Eaton
  • George J. Brewer
  • Jerome S. Schultz
  • Charles F. Sing
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 6)


The discovery of the effects of 2,3-diphosphoglycerate (DPG) and adenosine triphosphate (ATP) on the oxygen dissociation characteristics of hemoglobin (Chanutin & Curnish, 1967; Benesch & Benesch, 1967) has greatly increased our appreciation of the association between red cell metabolism and function. Recent evidence makes it clear that, through variations in the levels of ATP and DPG, the metabolism of the human red cell may help maintain normoxia. Increases in the concentration of DPG will produce corresponding decreases in the oxygen affinity of hemoglobin. Elevation of red cell DPG content and shifting of the hemoglobin-oxygen dissociation curve to higher pO2’s have been observed in a number of conditions characterized by hypoxia, such as exposure to high altitude (Lenfant et al., 1968; Eaton et al., 1968), anemia and pulmonary disease (Brewer & Eaton, 1969). Significant adjustments in the level of DPG in the circulating red cell may occur quite rapidly, as will be discussed in the paper by Faulkner (this volume).


Chronic Lymphocytic Leukemia Acute Leukemia Oxygen Delivery Oxygen Transport Oxygen Affinity 
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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • John W. Eaton
    • 1
  • George J. Brewer
    • 1
  • Jerome S. Schultz
    • 1
  • Charles F. Sing
    • 1
  1. 1.Depts. of Human Genetics, Medicine (Simpson Memorial Institute), and Chemical EngineeringUniversity of MichiganUSA

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