The Prediction of Poststorage Red Cell Viability From ATP Levels

  • Raymond J. Dern
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 6)


Of the many chemical and physical changes that occur in blood during storage,1–5 the poststorage erythrocyte adenosine triphosphate (ATP) level has the highest reported correlation with poststorage erythrocyte red cell viability (R = 0.94).6–8Although the correlation was great enough to be of predictive value for the regression, it was obviously not applicable to the estimation of expected cell viability from the ATP data for an individual unit of stored blood, Furthermore, the study was limited to blood which had been stored in acid-citrate-dextrose (ACD) U.S.P. formula A, or in citrate-phosphate-dextrose (CPD)8 solutions for either 21 or 28 days. The studies reported herein were undertaken for two primary reasons: (1) to expand the total number of cases and the experimental conditions of blood storage, and (2) to evaluate possible applications of the relationship.


Storage Period Adenosine Triphosphate Multiple Correlation Coefficient Extrapolation Procedure Blood Storage 
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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Raymond J. Dern
    • 1
    • 2
  1. 1.Department of MedicineLoyola University Stritch School of MedicineChicagoUSA
  2. 2.Department of HematologyHektoen Institute for Medical Research ChicagoChicagoUSA

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