A Comparison of Mechanisms of Oxygen Transport Among Several Mammalian Species

  • James Metcalfe
  • Dharam S. Dhindsa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 6)


One important function of the circulation is to provide oxygen to the peripheral tissues in quantities adequate for their metabolic needs. Since the final link in the chain of oxygen supply depends upon diffusion from capillary blood to the mitochondria, and since cellular oxygen tensions seem to be of the order of a few millimeters of mercury (Chance et al., 1962), the rate of oxygen diffusion is governed over short periods of time by the oxygen tension of capillary blood and the intercapillary diffusion distances (Krogh, 1941). Therefore, the first sentence of this paragraph could read that one important function of the circulation is to maintain an oxygen tension in tissue capillary blood adequate to supply tissue demands by diffusion.


Oxygen Tension Capillary Blood Blood Oxygen Mixed Venous Blood Blood Hemoglobin Concentration 
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  1. Adams, H. R., Boyd, E. M., Wilson, J. B., Miller, A. and Huisman, T. H. J. (1968). Arch. Biochem. Biophysics 127:398.CrossRefGoogle Scholar
  2. Bartels, H. (1964). The Lancet 2:599.CrossRefGoogle Scholar
  3. Bartels, H., Beer, R., Fleischer, E., Hoffheinz, H. J., Krall, J., Rodewald, G., Wenner, J. and Witt, I. (1955). Pflügers Arch. Ges. Physiol. 261:99.CrossRefGoogle Scholar
  4. Chance, B., Cohen, P., Jobsis, F. and Schoener, B. (1962). Science 137:499.PubMedCrossRefGoogle Scholar
  5. Dhindsa, D. S., Hoversland, A. S., Neill, W. A. and Metcalfe, J. (In preparation).Google Scholar
  6. Harkness, D. R., Ponce, J. and Grayson, V. (1969). Comp. Biochem. Physiol. 28:129.PubMedCrossRefGoogle Scholar
  7. Huisman, T. H. J., Adams, H. R., Dimmock, M. O., Edwards, W. E. and Wilson, J. B. (1967). J. Biol. Chem. 242:2534.PubMedGoogle Scholar
  8. Huisman, T. H. J., Brandt, G. and Wilson, J. B. (1968). J. Biol. Chem. 243:3675.PubMedGoogle Scholar
  9. Korner, P. I. and Darian Smith, I. (1954). Austral. J. Exptl. Biol. 32:499.CrossRefGoogle Scholar
  10. Krogh, A. (1941). The Comparative Physiology of Respiratory Mechanisms. Dover Publications, Inc., New York.Google Scholar
  11. Metcalfe, J., Hoversland, A. S., Erickson, L. F., Rogers, A. L. and Clary, P. L. (1968). In: Animal Models for Biomedical Research. Publication #1594, National Academy of Science, Washington, D. C., pp. 55–63.Google Scholar
  12. Parer, J. T., Jones, W. D. and Metcalfe, J. (1967). Resp. Physiol. 2:196.CrossRefGoogle Scholar
  13. Parer, J. T. and Metcalfe, J. (1967). Nature. 215:653.CrossRefGoogle Scholar
  14. Severinghaus, J. W. (1961). In: Blood and Other Body Fluids., edited by P. L. Altman and D. S. Dittmer. Federation of American Societies for Experimental Biology, Washington, D. C., p. 165.Google Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • James Metcalfe
    • 1
  • Dharam S. Dhindsa
    • 1
  1. 1.Heart Research LaboratoryUniversity of Oregon Medical SchoolPortlandUSA

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