Adaptation of the Red Blood Cell to Muscular Exercise

  • John A. Faulkner
  • George J. Brewer
  • John W. Eaton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 6)


The shift to the right in the oxygen dissociation curve of vigorously exercising subjects beyond that attributable to the decrease in blood pH and/or the increase in blood temperature has been noted by several investigators (Mitchell et al., 1958; Rowell et al., 1964; Sproule and Archer, 1959). The right shift is more pronounced in venous than arterial blood because of the greater decrease in pH (Sproule et al., 1960) and the slight increase in temperature (Sproule and Archer, 1959) of the venous compared to the arterial blood. Mitchell et al., (1958) recognized the potential of the right shift in the oxygen dissociation curve to maintain an adequate tissue oxygen gradient or to increase oxygen unloading at a given tension. However, they concluded that the mechanism was unknown.


Oxygen Uptake Blood Lactate Maximum Exercise Skeletal Muscle Cell Maximum Oxygen Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Aste-Salazar, H. and Hurtado, A. (1944). Am. J. Physiol. 142:733.Google Scholar
  2. Astrand, I. (1960). Acta Physiol. Scand. 49:Suppl. 169.Google Scholar
  3. Astrand, P.-O., Fallback, I., Hedman, R., and Saltin, B. (1963). J. Appl. Physiol. 18:619.Google Scholar
  4. Astrand, P.-C., and Saltin, B. (1961a). J. Appl. Physiol. 16:971.PubMedGoogle Scholar
  5. Astrand, P.-O., and Saltin, B. (1961b). J. Appl. Physiol. 16:977.PubMedGoogle Scholar
  6. Balke, B. (1963). Proceedings of First Canadian Fitness Seminar 1:5.Google Scholar
  7. Benesch, R., and Benesch, R. E. (1967). Biochem. and Biophys. Res. Commun. 26:162.CrossRefGoogle Scholar
  8. Brewer, G. J. and Eaton, J. W. (1969). J. Clin. Invest. (abst.). 48:11a.Google Scholar
  9. Carrow, R. S., Brown, R. E., and Van Huss, W. D. (1967). Anat. Record. 159:33.CrossRefGoogle Scholar
  10. Chanutin, A. and Curnish, R. R. (1967). Arch. Biochem. Biophys. 121:96.PubMedCrossRefGoogle Scholar
  11. Costill, D. L., and Fox, E. L. (1969). Med. Sci. Sports. 1:81.CrossRefGoogle Scholar
  12. Christensen, E. H., and Hogberg, P. (1950). Arbeits. 14:292.Google Scholar
  13. Davis, J. E. (1939). J. Lab. Clin. Med. 23:786.Google Scholar
  14. Dill, D. B., Edwards, H. T., and Talbot, J. H. (1935). J. Physiol. (Land.). 69:267.Google Scholar
  15. Eaton, J. W., Brewer, G. J., and Grover, R. F. (1969a). J. Lab. Clin. Med. 73:603.PubMedGoogle Scholar
  16. Eaton, J. W., Faulkner, J. A., and Brewer, G. J. (1969b). Physiologist (abst.). 12:212.Google Scholar
  17. Eaton, J. W., Faulkner, J. A., and Brewer, G. J. (1969c). Proc. Soc. Exp. Biol. (In Press).Google Scholar
  18. Ekblom, B., Astrand, P.-O., Saltin, B., Stenberg, J., Wallstrom, B. (1968). J. Appl. Physiol. 24:518.PubMedGoogle Scholar
  19. Faulkner, J. A. (1968). J. Am. Med. Assoc. 205:741.CrossRefGoogle Scholar
  20. Faulkner, J. A. (1970). In Physiology and Biochemistry of Muscle as a Food. Briskey, E. J., Cassens, R. G., Marsh, B. B., Eds. Univ. of Wisconsin Press. (In Press).Google Scholar
  21. Faulkner, J. A., Kollias, J., Favour, C. B., Buskirk, E. R., and Balke, B. (1968). J. Appl. Physiol. 24:685.PubMedGoogle Scholar
  22. Gollnick, P. D., Struck, P. J., Soule, R. G., and Heinrick, J. R. (1965), Arbeits. 21:169.Google Scholar
  23. Gordon, E. E., Kowalski, K., and Fritts, M. (1967). Arch. Phys. Med. Rehab. 48:296.Google Scholar
  24. Hakkila, J. E. (1955). Annales Med. Exper. Biol. Fenniae 33:Suppl. 10.Google Scholar
  25. Henneman, E., and Olson, C. B. (1965). J. Neurophysiol. 28:581.PubMedGoogle Scholar
  26. Hermansen, L., Hultman, E., and Saltin, B. (1967). Acta Physiol. Scand. 71:129.PubMedCrossRefGoogle Scholar
  27. Hermansen, L., and Saltin, B. (1969). J. Appl. Physiol. 26:31.PubMedGoogle Scholar
  28. Holmgren, A. and Linderholm, H. (1958). Acta Physiol. Scand. 44:203.PubMedCrossRefGoogle Scholar
  29. Holmgren, A., Mossfeldt, A. R., Sjostrand, T., and Strom, G. (1960). Acta. Physiol. Scand. 50:72.PubMedCrossRefGoogle Scholar
  30. Hultman, E., Bergstrom, J., and Anderson, N. McLennan (1967). Scand. J. Clin. Lab. Invest. 19:56.PubMedCrossRefGoogle Scholar
  31. Kjellberg, S. R., Rudle, U., and Sjostrand, T. (1949). Acta Physiol. Scand. 19:146.CrossRefGoogle Scholar
  32. Knehr, C. A., Dill, D. B., and Neufeld, W. (1942). Am. J. Physiol. 136:148.Google Scholar
  33. Lenfant, C., Torrance, J., English, E., Finch, C. A., Reynafarje, C., Ramos, J., and Fauru, J. (1968). J. Clin. Invest. 47:2652.PubMedCrossRefGoogle Scholar
  34. Marbach, E. P., and Weil, M. H. (1967). Clin. Chem. 13:314.PubMedGoogle Scholar
  35. Margaria, R. (1967). In Exercise at Altitude. Margaria, R. Ed. Exerpta Medica Foundation, New York. p. 15.Google Scholar
  36. Margaria, R., Cerretelli, P., and Mangili, E. (1964). J. Appl. Physiol. 19:623.PubMedGoogle Scholar
  37. Margaria, R., Oliva, R. D., Diprampero, P. E., and Cerretelli, P. (1969). J. Appl. Physiol. 26:752.PubMedGoogle Scholar
  38. Merton, P. A. (1956). J. Physiol. 123:553.Google Scholar
  39. Mitchell, J. H., Sproule, B. J., and Chapman, C. B. (1958). J. Clin. Invest. 37:538.PubMedCrossRefGoogle Scholar
  40. Oscari, L. B., Williams, B. T., and Hertig, B. A. (1968). J. Appl. Physiol. 24:622.Google Scholar
  41. Pollard, M. L., Cureton, T. K., and Greninger, L. (1969). Med. Sci. Sports. 1:70.Google Scholar
  42. Reeves, J. T., Grover, R. F., and Cohn, J. E. (1967). J. Appl. Physiol. 22:546.PubMedGoogle Scholar
  43. Romanul, F. C. A. (1965). Arch. Neurol. 12:497.PubMedCrossRefGoogle Scholar
  44. Rowell, L. B., Taylor, H. L., Wang, Y., and Carlson, W. S. (1964). J. Appl. Physiol. 19:284.PubMedGoogle Scholar
  45. Saltin, B. and Stenberg, J. (1964). J. Appl. Physiol. 19:833.PubMedGoogle Scholar
  46. Sproule, B. J. and Archer, R. K. (1959). J. Appl. Physiol. 14:983.PubMedGoogle Scholar
  47. Sproule, B. J., Mitchell, J. H., and Miller, W. F. (1960). J. Clin. Invest. 39:378.PubMedCrossRefGoogle Scholar
  48. Strydom, N. B., Wyndham, C. H., v. Radhenand, M., and Williams, C. G. (1962). Intern. Congr. Physiol. Sci., 22nd, Leiden. P.6.Google Scholar
  49. Taylor, H. L., Buskirk, E. R., and Henschel, A. (1955). J. Appl. Physiol. 8:73.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • John A. Faulkner
    • 1
  • George J. Brewer
    • 1
  • John W. Eaton
    • 1
  1. 1.Departments of Physiology, Medicine (Simpson Memorial Institute) and Human GeneticsThe University of Michigan Medical SchoolAnn ArborUSA

Personalised recommendations