Adaptation of the Red Blood Cell to Muscular Exercise

  • John A. Faulkner
  • George J. Brewer
  • John W. Eaton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 6)


The shift to the right in the oxygen dissociation curve of vigorously exercising subjects beyond that attributable to the decrease in blood pH and/or the increase in blood temperature has been noted by several investigators (Mitchell et al., 1958; Rowell et al., 1964; Sproule and Archer, 1959). The right shift is more pronounced in venous than arterial blood because of the greater decrease in pH (Sproule et al., 1960) and the slight increase in temperature (Sproule and Archer, 1959) of the venous compared to the arterial blood. Mitchell et al., (1958) recognized the potential of the right shift in the oxygen dissociation curve to maintain an adequate tissue oxygen gradient or to increase oxygen unloading at a given tension. However, they concluded that the mechanism was unknown.


Oxygen Uptake Blood Lactate Maximum Exercise Skeletal Muscle Cell Maximum Oxygen Uptake 


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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • John A. Faulkner
    • 1
  • George J. Brewer
    • 1
  • John W. Eaton
    • 1
  1. 1.Departments of Physiology, Medicine (Simpson Memorial Institute) and Human GeneticsThe University of Michigan Medical SchoolAnn ArborUSA

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