Systemic Oxygen Transport

  • Robert F. Grover
  • John V. Weil
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 6)


Normal tissue metabolism is intimately dependent upon an adequate supply of oxygen and it is the primary function of the oxygen transport system to supply this oxygen to the tissues. In a simple single-cell organism such as the amoeba transport of oxygen is accomplished by simple diffusion into the cell from the surrounding aqueous medium. Even insects are sustained by simple diffusion of oxygen from the surrounding atmosphere with the aid of a system of air ducts penetrating the body. However, when organisms are larger and more complex simple diffusion is no longer adequate to maintain oxygenation and a specific system must be introduced to transport oxygen from the surrounding environment to the cells of the body. The basic requirement for this system is to bring adequate quantities of oxygen to the tissues at sufficient partial pressure to permit rapid diffusion of oxygen in sufficient quantity from the blood to the tissue. The intracellular oxygen tension must be adequate to maintain metabolic processes. As long as these basic requirements are met, the oxygen transport system is a success. We will discuss two topics relating to this oxygen transport system. The first is the relationship between oxygen transport and the regulation of red cell production and the second considers the comparative physiology of oxygen transport in several animal species.


Oxygen Tension Arterial Oxygen Oxygen Transport Dissociation Curve Arterial Oxygen Saturation 
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  1. 1.
    Tenney, S. M-and Lamb, T-W.: Physiological consequences of hypoventilation and hyperventilation. In Handbook of Respiration, W. O. Fenn and Rahn editors. 1965. Amer. Physiol. Soc. Vol. II, p. 982.Google Scholar
  2. 2.
    Stohlman, F.: Erythropoiesis. New England J. Med. 26:342, 1967.Google Scholar
  3. 3.
    Weil, J. V., Jamieson, G., Brown, D. W., and Grover, R. F.: The red cell mass-arterial oxygen relationship in normal man. J. Clin. Invest. 47:1627–1639, 1968.PubMedCrossRefGoogle Scholar
  4. 4.
    Vogel, J. H. K., Goss, J. E., Mori, M., and Brammell, H. L.: Pulmonary circulation in normal man with acute exposure to high altitude (14,260 feet). Circulation 34:III–233, 1966.Google Scholar
  5. 5.
    Banchero, N., Will, J. A., and Grover, R. F.: Oxygen transport in the llama. Physiologist 12:166, 1969.Google Scholar
  6. 6.
    Reeves, J. T., Grover, E. B., and Grover, R. F.: Pulmonary circulation and oxygen transport in lambs at high altitude. J. Appl. Physiol. 18:560–566, 1963.Google Scholar
  7. 7.
    Lambertsen, C. J., Bunce, P. L., Drabkin, D. L., and Schmidt, C. F.: Relationship of oxygen tension to hemoglobin oxygen saturation in the arterial blood of normal men. J. Appl. Physiol. 4:873–885, 1952.PubMedGoogle Scholar
  8. 8.
    Blood O2 dissociation curves: Mammals. In Handbook of Respiration, D. S. Dittmer and R. M. Grebe editors. 1958, Philadelphia, Saunders, pp. 80.Google Scholar
  9. 9.
    Reeves, J. T., Grover, R. F., Filley, G. F., and Blount, S. G., Jr.: Cardiac output in normal resting man. J. Appl. Physiol. 16:276–278, 1961.PubMedGoogle Scholar
  10. 10.
    Otis, A. B.: The control of respiratory gas exchange between blood and tissues. In The regulation of human respiration, D. J. C. Cunningham and B. B. Lloyd editors, 1963. Oxford, Blackwell, pp. 11–119.Google Scholar
  11. 11.
    Donald, K. W., Wormald, P. N., Taylor, S. H., and Bishop, J. M.: Changes in the oxygen content of femoral venous blood and leg blood flow during leg exercise in relation to cardiac output response. Clin. Sci. 16:567–591, 1957.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Robert F. Grover
    • 1
  • John V. Weil
    • 1
  1. 1.Cardiovascular Pulmonary Research Laboratory, Division of Cardiology, Department of MedicineUniversity of Colorado Medical CenterDenverUSA

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